实验动物屏障环境常用消毒药品皮肤刺激实验  

Skin Irritation Caused by Commonly Used Disinfectants in Laboratory Animal Barrier Environment

作　　者：张大维[1] 邴国强[2] 徐彩云[1] 李萍[2] 杨东华[3] 于艳波[3] 刘占军[4] 郭超 

机构地区：[1]吉林大学基础医学院动物实验中心,长春130021 [2]吉林大学体育学院实验中心,长春130012 [3]吉林大学第二临床医学院实验动物观察室 [4]长春生物制品研究所实验动物室 [5]长春精优药业股份有限公司

出　　处：《中国比较医学杂志》2007年第2期102-104,共3页Chinese Journal of Comparative Medicine

基　　金：吉林省科技发展计划项目(项目编号吉科合字第20000200号)。

摘　　要：目的观察2%含量的过氧乙酸、0.2%含量的过氧乙酸、0.2%含量的次氯酸钠和2%含量的戊二醛溶液,对实验动物和工作人员皮肤是否有刺激性。方法2%含量的过氧乙酸、0.2%含量的过氧乙酸、0.2%含量的次氯酸钠和2%含量的戊二醛溶液短期接触豚鼠皮肤(斑贴)后,在规定的时间内,通过采用评分的方法来判定对豚鼠皮肤所产生的刺激反应。结果2%含量的戊二醛溶液对皮肤有轻微刺激,有水肿现象发生,1h后症状消失,并有棕黄色着色性,其他几种消毒药品均对豚鼠皮肤无刺激性反应。结论2%含量的戊二醛溶液对实验动物和工作人员皮肤有轻微刺激,并有棕黄色着色性。Objective To investigate whether commonly used disinfectants cause skin irritation reactions in laboratory animals and personnel. Methods The following disinfectants were used in this experiment： 2% peracetic acid, 0.2% peracetic acid, 0.2% sodium hypoehlorite and 2% giutaraldeldehyde. After short-term contact with the skin of guinea pigs （spot）, the irritation reactions were evaluated. Results 2% glutaraldeldehyde solution caused slight skin erythema and edema, vanished after 1 hour, and a yellowish brown coloration was left. Other several kind of disinfectants did not lead to apparent skin irritation reactions in the guinea pigs. Conclusions 2 % glutaraldehhyde solution may cause slight skin irritation reaction and yellowish brown coloration in both experimental animal and may be harmful to personnel.

关 键 词：消毒剂 过乙酸 次氯酸钠 戊二醛 皮肤 刺激 豚鼠 

分 类 号：R285.5[医药卫生—中药学]