儿童接种乙肝疫苗后乙肝表面抗原携带状况分析  

Seroepidemiological surveillance of HBsAg in children after HB vaccination

作　　者：余加席[1] 刘社兰[2] 翟祥军[2] 邱祥鹏 胡传强[4] 

机构地区：[1]徐州市疾病预防控制中心,江苏徐州221006 [2]江苏省疾病预防控制中心 [3]沛县疾病预防控制中心 [4]新沂市疾病预防控制中心

出　　处：《中国校医》2007年第1期14-15,共2页Chinese Journal of School Doctor

摘　　要：目的了解徐州市乙肝疫苗纳入计划免疫后出生儿童HBsAg携带状况，探讨母婴传播的作用，为采取进一步控制措施提供依据。方法采用整群分层随机抽样的方法。选择3061名1992～2004年出生的儿童作为研究对象，检测HBsAg。采用病例对照研究分析部分儿童母亲感染与儿童感染的关系。结果1992～1994、1995～1997、1998～2000、2001～2004年出生儿童的HBsAg阳性率分别为5．31％、1．51％、0．76％、0．87％。母亲HBsAg阳性是其子女成为HBsAg携带者的重要危险因素（OR=25．67），儿童HBsAg阳性大部分归因于母婴传播且随儿童年龄降低而升高。其中，1992～1997年出生儿童HBsAg阳性归因于母亲HBsAg阳性的比例为52．38％，1998～2004年出生儿童HBsAg阳性归因于母亲HBsAg阳性的比例为95．12％。结论徐州市儿童HBsAg阳性率已处于较低水平，控制乙肝母婴垂直传播是进一步降低儿童HBsAg携带率的关键环节。Objective To understand the status of children＇s HBsAg carrier after HB vaccination and explore the causes. Methods Cluster sampling method was used to select 3 061 children horn from 1992 to 2004. ELLSA was used to test HBsAg. A case-control study was performed to analysis the causes of HBsAg positive, Results The HBsAg positive rates were 5.31%, 1.51%, 0, 76%, and 0.87%, in the children born from 1992 to 1994, 1995 to 1997, 1998 to 2000 and 2001 to 2004, respectivdy. The children＇s carriers of HBsAg were most attributed to mother-infant transmission （ OR = 25.67）, and the rate was rising with the children＇ s age reducing. The percent of HBsAg positive in the children attributable to their mother were 52.38% and 95.12% from 1992 to 1997 and from 1998 to 2004, respectively. Conclusions The HBsAg positive rate is much lower in children after FIB vaccination program in Xuzhou City. It is the key to control mother-infant transmission for further HB infection control.

关 键 词：乙肝疫苗 乙肝表面抗原 母婴传播 

分 类 号：R512.62[医药卫生—内科学]