彝族健康人群外周血T淋巴细胞正常参考值研究  

MEASUREMENT OF T LYMPHOCYTE CELL NORMAL REFERENCE RANGES IN YI MINORITY YOUTHS AND ADULTS

作　　者：卫大英[1] 马名驹[1] 马志凌[1] 边仕超[1] 马兆瑾[1] 肖林[1] 潘璐[1] 毛木呷[1] 

机构地区：[1]四川省凉山州疾病预防控制中心,西昌615000

出　　处：《现代预防医学》2007年第3期416-418,共3页Modern Preventive Medicine

基　　金：国家十五科技攻关项目(2004BA719A01);国家自然科学基金项目(30571612;10501052);中国疾病预防控制中心性病艾滋病预防控制中心开展"中国健康青少年及成人外周血T淋巴细胞正常参考值研究"项目

摘　　要：[目的]了解四川省凉山地区彝族青少年及成人CD3、CD4、CD8计数及CD4/CD8比值,初步建立彝族青少年及成人外周静脉血CD3、CD4、CD8淋巴细胞绝对数值和CD4/CD8比值的正常参考范围。[方法]对彝族健康人血标本进行现况调查,根据不同性别,不同年龄分别进行比较,用Becton Dickinson公司生产的FAcscount自动化流式细胞仪进行CD4、CD8计数及CD4/CD8比值计算,并进行分析。[结果]CD4正常值在不同性别之间差异无统计学意义,在部分年龄组之间差异有统计学意义,CD4正常平均值为865.77±304.54;CD8及CD4/CD8在不同性别之间及部分年龄组之间差异有统计学意义,CD8计数平均值为674.28±273.63,CD4/CD8平均值为1.38±0.51。[结论]凉山彝族正常人群CD4淋巴细胞绝对值与美国CDC公布的结果相似,建议对彝族人群获得性免疫缺陷综合症CD4平均值的诊断临界值建议可采用500/mm3。[Objective] To observe CD3, CD4, CD8 and CD4/CD8, to measure the absolute value of CD3. CD4 and CD8 in circumferential venous blood and reference range of CD4/CD8 ratio in Yi minority youths and adults from Liangshan prefecture. [Methods] CD4 and CD8 value and CD4/CD8 ratio were measured through flow cytometry produced by Becton Dickinson company in Yi minority youths and adults blood specimens and were analyzed according to defferent age and sex. [ Results] There were significant difference in CD4 value among part of different age groups but no difference among different sex groups, and the mean value of CD4 was 865.77±304.54; There were significant difference in CD8 value and CD4/CD8 ratio among different age and sex groups, and the mean value of CD8 CD4/CD8 ratio was 674.28±273.63, 1.38±0.51 respectively. [Conclusions] The mean value of CD4 in Yi minority adults.of Liangshan prefecture is similar with that in American, so 500/ram3 can be used as critical value of CD4 mean value of Yi minority adults with AIDS.

关 键 词：人类免疫缺陷病毒 CD4淋巴细胞计数 彝族 CD4/CD8比值 流式细胞仪 

分 类 号：R195[医药卫生—卫生统计学]