子宫内膜异位症患者外周血单个核细胞T细胞亚群、mIL-2R表达及临床意义  

EXPRESSION OF T SUBSETS AND MIL-2R IN PERIPHERAL BLOOD OF PATIENTS WITH ENDOMETRIOSIS AND ITS CLINICAL MANIFESTATION

作　　者：孙琳[1] 万莉[2] 胡昌玲[2] 王健[1] 

机构地区：[1]安徽理工大学医学院妇产科护理学教研室,淮南232001 [2]淮南市妇幼保健院妇产科

出　　处：《现代预防医学》2007年第3期467-468,共2页Modern Preventive Medicine

摘　　要：[目的]探讨子宫内膜异位症患者外周血单个核细胞(PBMC)T细胞亚群、mIL-2R表达及临床意义。[方法]用生物素-链霉亲素(BSA)法检测T细胞亚群和mIL-2R表达水平,以PHA体外诱导PBMC中mIL-2R表达。[结果]子宫内膜异位症患者CD3+、CD4+、CD8+及CD4+/CD8+比值分别为(38.9±7.0)%、(29.2±6.6)%、(23.9±4.2)%、1.3±0.5;PHA诱导前后mIL-2R表达水平分别为(3.9±1.2)%和(21.7±5.3)%,与正常对照相比,差异有统计学意义(P﹤0.5)。[结论]子宫内膜异位症患者存在定程度细胞免疫功能低下表现,T细胞活化障碍,并参与子宫内膜异位症的致病过程。[ Objective] To study the level of T subsets and mIL-2R in peripheral blood of patients With endometriosis and its clinical manifestation. [Mehtods] The expressions of T subsets and mIL-2R in silence and inducement were respectively detected by method of biotin-streptavidin （BSA） . [ Results] The levels of CD3^＋. CD4^＋. CD8^＋ in peripheral blood of patients with endometriesis were（38.9±7.0）%. （29.2±6.6）%. （23.9±4.2）%, and the rate of CD4^＋/CD8^＋ was 1.3±0.5, and the levels of mIL-2R before and after inducement of PHA were （3.9±1.2）% and （21.7±5.3）%, respectively. There was highly significant difference between experimental group and control group （P〈 0.5） . [Conclusions] There are low cellular immune function in the patients with endometriesis and handicap of T cells which may take part in the course of pathogen .

关 键 词：子宫内膜异位症 外周血单个细胞(PBMC) T细胞亚群 膜白介素-2受体 (mIL-2R) 

分 类 号：R711.71[医药卫生—妇产科学]