复发性脑梗死的危险因素分析  

ANALYSIS ON THE RISK FACTORS ASSOCIATED WITH PROGRESSIVE STROKE

作　　者：肖淑萍[1] 吉中国[2] 朱海英[1] 

机构地区：[1]济南市第四人民医院神经内科,济南250031 [2]山东省立医院老年神经科

出　　处：《现代预防医学》2007年第3期497-498,501,共3页Modern Preventive Medicine

摘　　要：[目的]研究与复发性脑梗死有关的危险因子。[方法]收集2002、8-2004、7在山东省立医院神经内科住院的573例急性脑梗死病人,依据文献将573例急性脑梗死患者分为复发组和初发组。对2组患者的临床表现及炎症参数(血白细胞、C-反应蛋白)、平均血小板体积、红细胞、凝集参数(D-二聚体、纤维蛋白原、凝血酶原时间)、血脂、血糖、血压采用Chi-squaretest,independent-sample t test和logistic多因素逐步回归法来评价进展性中风的危险因子。[结果]在573例病人中,172例(25.6%)为复发性脑梗死。病情的复发与白细胞(t=-5.950,P﹤0.001)、平均血小板体积(t=-7.116,P﹤0.001)、C-反应蛋白(t=-3.420,P﹤0.001)、血糖增高(t=-8.27,P﹤0.001)及糖尿病史明显相关(χ2=11.85,P﹤0.005)。[结论]复发性脑梗死与白细胞数、慢性炎症和糖尿病有关。控制慢性炎症如白细胞数、平均血小板体积、C-反应蛋白和血糖可以减少复发性脑卒中。[ Objective] To investigate the risk factors associated with recurrent stroke. [ Methods] Five hundred and seventy-three inpatients with acute cerebral infarction from 2002.8 to 2004.7 in department of neurology in the People＇s Hospital of Shandong province were collected. They were derided into recurrente strokeand first Stroke patients. Recurrente stroke and first stroke patients were compared regarding clinical profile, inflammatory parameters （leukocytes, C-reactive protein）, red cell, mean platelet volume, Coagulation parameters （fibrinogen, D--dimer, PT）, triglycerides, total cholesterol、 blood glucose and blood pressure. Chi-square test, independent-sample t test and logistic, multiple stepwise regression were employed to evaluate the risk factors for recurrent stroke. [Results] Among the five hundred and seventy-three patients, one hundred and seventy-two （25.6%） showed recurrent stroke, which was significantly associated with a higher leukocyte counte （t = -5.950, P〈0.001）, higher mean plate.let volume （t= -7.116, P〈0.001）, higher C-renetive protein （t= -3.420, P〈0.001）, higher blood glucose （t = -8.27, P 〈0.001） and history of diabetes mellitus （x^2= 11.85, P 〈0.005） . [Conclusions] Recurence in cerebral infarct may be related to leukocyte count, chronic inflammation and history of diabetes mellitus. The control of leukocyte count, mean platelet volume, C-reactlve and protein end blood glucose can degrade the incidence rate of recurrent stroke.

关 键 词：复发性脑梗死 危险因素 分析 

分 类 号：R195.4[医药卫生—卫生统计学]