一种新型的骨组织工程用支架材料的制备与性能表征  

The peparation and characterization of novel scaffold materials for bone tissue engineering

作　　者：王德平[1] 黄文旵[1] 周萘[1] 姚爱华[1] 宁佳[1] 刘欣[1] 

机构地区：[1]同济大学材料科学与工程学院,上海200092

出　　处：《功能材料》2007年第2期302-304,307,共4页Journal of Functional Materials

基　　金：上海市科委重大基础研究资助项目(05DJ14006)

摘　　要：以硼硅酸盐玻璃粉为原料,采用有机泡沫浸渍工艺,制备了高孔隙率的网眼多孔支架。应用XRD、SEM及ICP-AES等对硼酸盐生物玻璃粉末在生理模拟液中的降解性能、生物活性等进行了测试分析。结果表明,硼硅酸盐生物玻璃的降解性和生物活性与材料的组成配比有关,因此,可以通过调整玻璃的组成有效控制材料的降解性和表面形成的羟基磷灰石晶体的形态。硼硅酸盐生物活性玻璃作为硬组织工程支架材料的研究具有重要的意义和广泛的应用前景。Three-dimensional （3D） ,highly porous scaffolds with interconnected pore morphotogies stmttar to trabecular bone have been fabricated by polymer sponge method using melt-derived borosilicate glass powder. The biodegradation and bioactivity of borosilicate glass powder were investigated in vitro method combined with XRD, SEM and ICP-AES techniques. It indicated that there is a connection between the composition of materials and the biodegradation,as well as bioactivity. The degradation rate can be adjusted by the boron concentration in the bioglass. It indicated that borosilicate glass is a promising scaffolds biomaterial for bone tissue engineering.

关 键 词：支架材料 硼硅酸盐玻璃 生物活性玻璃:生物降解性 生物活性 

分 类 号：TB321[一般工业技术—材料科学与工程]