非血缘异基因脐血移植治疗SAA可行性研究  

Study on treatment for six severe aplastic anemia patients by unrelated allagene cord blood transplantation

作　　者：黄宁[1] 葛林阜[1] 姜夕锋 刘希民[1] 郭鹏[1] 周芳[1] 

机构地区：[1]济南军区总医院,山东济南250031 [2]山东省脐带血造血干细胞中心

出　　处：《山东医药》2007年第4期7-8,共2页Shandong Medical Journal

摘　　要：目的 评价非血缘脐血移植（UCBT）治疗急性重型再生障碍性贫血（SAA）的疗效。方法 SAA患者6例，采用环磷酰胺和抗胸腺细胞球蛋白预处理方案；移植方式为HLA不全相合UCBT；应用环孢素A和骁悉预防移植物抗宿主病（GVHD）。随访时间为60～1358d。结果 移植后12～38d造血重建。短串联重复序列-聚合酶链反应分析显示移植后17～150d基因型表现为完全性患者型，未发生GVHD。血常规、骨髓象检查正常。结论 非血缘HLA配型不合的脐血用于治疗SAA是可行的。[Objective] To evaluate the effect of unrelated cord blood transplantation（UCBT） in treatment for severe aplastic anemia（SAA）. [Methods] Six acute SAA patients were enrolled in the study. The conditioning regimen consisted of cyclophosphamide and antilymphocytic globulin. HLA unmatched UCBT were taken as transplanting mode graft-versus-bost disease （GVHD）. Prophylaxis regimens consisted of cyclosporine and mycophenolate mofetil. Follow-up duration is 60-1358 days. [Results] Hematopoiesis reconstitution Occurred on 12- 38 days after transplantation. Genetype is in the same aspatients on 17-150 days after transplantation by STRPCR. No GVHD occurred in the follow-up duration. The periphery blood routine and bone marrow routine were both normal. [Conclusion] It is feasible to cure SAA with HLA unmatched UCBT.

关 键 词：贫血 再生障碍性 脐血移植 非血缘 HLA抗原 

分 类 号：R556.5[医药卫生—血液循环系统疾病]