螺内酯、氯沙坦对AMI大鼠血浆胶原代谢产物及心肌组织心钠素、醛固酮的影响  

Impact of spironolactone,losartan on the plasma collagen metabolism and cardiac atrial natriuretic peptide,aldosterone levels in AMI rats

作　　者：李侠[1] 董士民[1] 刘坤申[2] 

机构地区：[1]河北医科大学第三医院,河北石家庄050051 [2]河北医科大学第一医院

出　　处：《山东医药》2007年第4期21-22,共2页Shandong Medical Journal

基　　金：河北省科学技术研究与发展指导计划(052761200)

摘　　要：目的探讨螺内酯、氯沙坦对急性心肌梗死(AMI)大鼠血浆胶原代谢产物及心房利纳系统的影响。方法将AMI大鼠模型随机分成假手术组、AMI对照组、螺内酯组(S组)、氯沙坦组(L组)及合用组(S+L组)。测定血浆Ⅲ型前氨基胶原末端肽(PⅢNP)、Ⅰ型前胶原羧基末端肽(PⅠ CP)、血浆和心肌血管紧张素Ⅱ(AngⅡ)、心钠素(ANP)、醛固酮(Ald)水平。结果①与AMI组比较,第2、6周L组、S组血浆PⅢNP、PⅠ CP均逐渐降低(P<0.05,P<0.01)。S组第2、6周血浆ANP逐渐下降(P<0.01);L组第2、6周血浆AngⅡ、ANP水平分别显著下降(P<0.01)。②与S及L组相比,S+L各时间点血浆ANP均显著降低(P<0.01)。2与AMI组相比,第2、6周S组心肌ANP水平显著降低(P<0.01),L组与AMI组比、L组、S+L组同S组相比,心肌AngⅡ、Ald和ANP均显著降低(P<0.01)。S+L组与L组相比,心肌ANP显著降低(P<0.01)。结论螺内酯及氯沙坦可降低血浆PⅢNP、PⅠ CP和血浆、心肌组织ANP水平,二者联用有显著叠加效应。[Objective] To investigate the effects of spironolactone, losartan on the plasma collagen metabolism and cardiac atrial natriuretic peptide,aldosterone levels in acute myocardial infarction （AMI） rats. [Methods] AMI rats Were randomly divided into sham operation group, AMI group,spironolactone group （S）, losartan group （L）, combination group（S＋L）. The levels of plasma P Ⅲ NP, P Ⅰ CP, Ang Ⅱ , ANP and Aid were measured. [Results] （1）In comparison with AMI groups, the levels of plasma P Ⅲ NP and P Ⅰ CP in S groups and L groups both decreased （P〈0. 05, P〈0. 01 ） at 2,6 weeks. ANP level in S group decreased gradually at 2,6 week（P〈0.01）. Ang Ⅱ and ANP levels in L group were decreased remarkahly （P〈0.01）. In comparison to S group and L group, ANP level of combination group in single time decreased remarkably （P〈0. 01）. （2） In comparison with AMI groups, plasma ANP levels in Sgroups decreasedat on 2th 6th week. （P〈0. 01）,and plasma Ang Ⅰ ,Ald and ANP levels decreased remarkably in L groups on 2th, 6th week （P〈0.01）. In comparison with S group,the levels of Ang Ⅱ ,Ald and ANP in combination group decreased remarkably （P〈0.01）. The level of ANP in combination group was lower than L group （P〈0. 01）. [Conclusion] Spironolactone and lostartan can lower the levels of P ⅢNP, P Ⅰ CP, Plasma and cardiac ANP. More effects produced by combination therapy.

关 键 词：心肌梗死 胶原 心钠素 醛固酮 螺内酯 

分 类 号：R541.4[医药卫生—心血管疾病]