对氨基苯甲磺酰吡咯烷的合成  

Synthesis of 1-(4-Aminophenylmethane sulfonyl)pyrrolidine

作　　者：王尊元[1] 王钟瑾[2] 王国强[1] 

机构地区：[1]浙江省医学科学院,杭州310013 [2]浙江大学附属第二医院,杭州310009

出　　处：《齐鲁药事》2007年第2期106-107,共2页qilu pharmaceutical affairs

摘　　要：目的合成得到选择性5-HT1B/1D受体激动剂阿莫曲普坦的关键中间体对氨基苯甲磺酰吡咯烷。方法以氯苄为起始原料经过硝化、磺化、氯化、氨解、还原硝基等多步反应得到目标产物。结果与结论实验成功得到目标产物并且新的合成路线操作简便,便于工业化生产。OBJECTIVE To obtain the key intermediate of almotriptan, 1-（4-Aminophenylmethane sulfonyl） pyrrolidine. METHODS Using benzyl chloride as initial material, the goal product was synthesized by nitration,sulfonylation,chlorination,aminolysis and reduction. RESULTS anti CONCLUSION The goal product was obtained successfully,and this synthetic route had the advantage of easy operation and suitable for industrialization.

关 键 词：对氨基苯甲磺酰吡咯烷 合成 阿莫曲普坦 中间体 

分 类 号：TQ460.6[化学工程—制药化工]