乙肝III号内外合用治疗慢性乙型肝炎后肝纤维化63例  

Long-term efficacy of combined internal and external application of Ganyan Sanhao in treatment of liver fibrosis resulted from chronic hepatitis B

作　　者：邢宇锋[1] 张希[1] 邵丽[1] 王丽娜[1] 童光东[1] 

机构地区：[1]广州中医药大学附属深圳医院肝病科,广东省深圳市518033

出　　处：《世界华人消化杂志》2007年第5期522-527,共6页World Chinese Journal of Digestology

基　　金：深圳市科技资助项目;NO.200204239~~

摘　　要：目的:观察乙肝Ⅲ号内外合用治疗慢性乙型肝炎后肝纤维化的远期疗效.方法:随机选择乙肝肝纤维化患者240例,分为乙肝Ⅲ号外用膏组(n=58),内服组(n=62),内外合用组(n=63),对照组(n=57).治疗后3mo,观察各组临床症状、肝功能、肝纤维化指数、PGA参数、血液动力学等.结果:4组皆能改善临床症状,但以内外合用组为著;4组改善肝功能、肝纤三项、PGA参数,治疗后3mo以内外合用组疗效显著(t=6.1201,P=0.000;t=20.8201,P=0.000;t=20.5154,P=0.000);血液动力学检测显示,各治疗组治疗后门、脾静脉血管直径、血流量皆有下降(t=3.6153,P=0.0004;t=6.8052,P=0.000),内外合用组血流量下降明显(t=6.3969,P=0.000).随访12mo后仍是内外合用组疗效为优.但各组在抗病毒指标上,无统计学意义.结论:乙肝Ⅲ号内外合用治疗乙肝后肝纤维化有一定远期疗效,且较单一方法疗效明显,疗程以3mo为优.AIM： To observe the prospective efficacy of integrated internal and external application of Yigan Sanhao （YGSH） in the treatment of liver fibrosis resulted from chronic hepatitis B （CHB）. METHODS： A total of 240 inpatients with CHBinduced liver fibrosis were randomly divided into group A （n = 58）, B （n = 62）, C （n = 63） and D （n = 57）. External, internal and integrated external and internal treatments of YGSH were performed on the patients of group A, B, and C, respectively. The patients of group D served as controls. The clinical symptoms, liver function, fibrosis and PGA parameters, and hernodynamic changes were observed 3 months after treatment. RESULTS： The clinical symptoms were improved, especially in group C. The liver function, fibrosis and PGA parameters were also ameliorated 3 months after treatment in all the groups, especially in group C （t = 6.1201, P = 0.000; t = 20.8201, P = 0.000; t = 20.5154, P = 0.（300）. Hemodynamic examination showed that the diameters of splenic and portal vein as well as the blood flow were decreased in all the groups （t = 3.6153, P = 0.0004; t = 6.8052, P = 0.000）, especially significant in group C （t = 6.3969, P = 0.000）. A 12-rnonth following-up demonstrated that combination of external and internal application had the most favorable effect. However, the anti-viral efficacy was not markedly different between the four groups. CONCLUSION： Integrated internal and external application of YGSH has a favorable longterm efficacy, and it is superior to the single use, Three-month course is considered the most optimal.

关 键 词：慢性乙型肝炎 肝纤维化 中药 内外合用 

分 类 号：R259[医药卫生—中西医结合]