运脾润肠法对慢传输型功能性便秘胃肠激素的影响  

Effect of spleen activation and intestine moistening on gastrointestinal hermone in slow-transit constipation

作　　者：姜国平[1] 何凌[1] 霍岭霞[2] 胡珂[1] 徐友妹[3] 

机构地区：[1]江西中医学院附属医院消化内科,江西省南昌市330006 [2]江西中医学院 [3]江西中医学院附属医院检验科,江西省南昌市330006

出　　处：《世界华人消化杂志》2007年第5期537-540,共4页World Chinese Journal of Digestology

摘　　要：目的:观察中医运脾润肠法治疗慢传输型便秘(slow-transit constipation,STC)的临床疗效及对血清一氧化氮(NO)、血浆P物质(SP)水平的影响.方法:选择确诊为STC患者90例随机分为2组应用秘通治疗60例,莫沙必利治疗30例,并设正常对照组30例,采用放射免疫法(RIA)测定中药治疗组及西药对照组治疗前、后空腹状态血清NO和血浆SP水平.结果:中药治疗组临床症状总有效率为93.3%西药对照组为73.3%,两组对比有显著性差异(P<0.05),且前者临床痊愈率为20%,明显高于西药对照组0%(P<0.05).治疗前,中药治疗组和西药对照组血浆SP水平低于正常组,血清NO水平高于正常组.治疗后,西药对照组NO及SP与正常组对比仍有显著性差异(NO70.53±9.48μmol/Lvs62.56±10.01μmol/LP<0.05;SP:30.15±5.25μmol/Lvs34.55±4.39μmol/L,P<0.05),而中药组(NO:66.24±14.09μmol/L;SP:34.36±6.35μmol/L)与对照组无显著差异(P>0.05).结论:采用中医运脾润肠法治疗STC患者疗效显著,能调节血清NO和血浆SP浓度,推动肠道蠕动,促进肠道排空,从而改善患者临床症状.AIM： To assess the therapeutic efficacy of spleen activation and intestine moistening for solwtransit constipation as well as its effect on the levels of gastrointestinal neurotic mediators such as serum nitric oxide （NO） and plasma substance P （SP） . METHODS： A total of 90 patients with slowtransit constipation were divided into group A （n = 60） and B （n = 30）, treated with Mitong （a Chinese medicine for spleen activation and intestine moistening） and mosapride, respectively. Another 30 healthy individuals served as controls. Radioimmunoassay was used to examine the levels of serum NO and plasma SP before and after treatment. RESULTS： The total efficacy rate for clinical symptom was significantly higher in group A than that in group B （93.3% vs 73.3%, P 〈 0.05）, and the cure rate was also significantly higher in group A （20% vs 0%, P 〈 0.05）. Before treatment, the serum level of NO was higher while the plasma level of SP was lower than that group C. After treatment, NO and SP levels in group B were still significant different from those in group C （NO： 70.53 ± 9.48 μmol/L vs 62.56 ± 10.01 μmol/L, P 〈 0.05; SP： 30.15 ± 5.25 μmol/L vs 34.55 ± 4.39 μmol/L, P 〈 0.05）, but they were not markedly different between group A （NO： 66.24 ± 14.09 μmol/L; SP： 34.36 ± 6.35 μmol/L） and C. CONCLUSION： The therapy of spleen activation and intestine moistening is effective for slowtransit constipation, and it can regulate the levels of serum NO and plasma SP.

关 键 词：运脾润肠法 慢传输型便秘 一氧化氮 P物质 

分 类 号：R256.35[医药卫生—中医内科学]