自发性高血压大鼠脑底动脉含神经肽Y、含降钙素基因相关肽、含P物质神经的变化  

CHANGES OF NEUROPEPTIDE Y-, CALCITONIN GENE RELATED PEPTIDE-,SUBSTANCE P-IMMUNOREACTIVE NERVE FIBERS IN THE CEREBRAL ARTERIES OF THE SPONTANEOUSLY HYPERTENSIVE RAT

作　　者：毛秦雯[1] 苏慧慈[1] 

机构地区：[1]第四军医大学基础部组织学与胚胎学教研室

出　　处：《神经解剖学杂志》1996年第3期251-255,共5页Chinese Journal of Neuroanatomy

摘　　要：用免疫组织化学（ＡＢＣ）方法，观察了含ＮＰＹ、含ＣＧＲＰ和含ＳＰ神经在自发性高血压大鼠脑底动脉的变化．结果表明，和对照用的京都Ｗｉｓｔａｒ大鼠相比，含ＮＰＹ神经在脑底动脉环吻侧的密度略低，而尾侧略高；自发性高血压大鼠大脑前动脉和大脑后动脉含ＮＰＹ神经纵行纤维密度比对照大鼠低，而环行纤维密度比对照大鼠高．自发性高血压大鼠脑底动脉含ＳＰ和含ＣＧＲＰ神经的密度均比对照大鼠低．本文对上述变化的意义进行了讨论．In this study, the irnmunohistochemistry ABC technique was used to investigate the changes of NPY-, CGRP-, SP-IRnerve fibers in the entire Willis circle of the Spontaneously Hypertensive Rats (SHR). The results showed that in SHR thedensities of NPY-IR nerves on the rostal part of the Willis circle were higher and that on the caudal part of the circle werelower than that in normal control Wistar-Kyoto(wky) rats. In the anterior cerebral arteries (ACA) and posterior cerebralarteries(PCA) of SHR, the densities of NPY-IR nerve fibers running longitudinally were higher and that of NPY-IR nerveibers running spirally were lower than that in ACA and PCA of WKY rats. The densities of SP-IR and CGRP-IR nervesfibers in Willis circles of SHR were lower than that of WKY rats. The article discussed the significance of the differences ofpeptide containing nerves in cerebral arteries between SHR and WKY rats.

关 键 词：高血压 神经肽Y 降钙素基因 相关肽 P物质 

分 类 号：R544.102[医药卫生—心血管疾病]