人胚胎海马发育的形态学研究Ⅲ．肽能神经元的发生  

THE MORPHOLOGIC STUDIES OF HUMAN FETAL HIPPOCAMPAL DEVELOPMENTⅢ. HISTOGENESIS OF PEPTIDERGIC NEURONS

作　　者：邓锦波[1] 蔡琰[1] 黎曰真[1] 项守仁[1] 苏敏[1] 孙晓江[1] 张毅[1] 

机构地区：[1]上海第二医科大学附属仁济医院神经生物学实验室,江西医学院

出　　处：《神经解剖学杂志》1996年第3期256-260,共5页Chinese Journal of Neuroanatomy

摘　　要：利用Ｇｏｌｇｉ镀银法、免疫组织化学法，对不同胎龄人肛胎海马的肽能神经元进行了研究．发现ＳＳ阳性神经元于胚胎１９周出现，ＳＰ阳性神经元、ＮＰＹ阳性神经元于１７周出现，ＧＡＢＡ阳性神经元在１６周即已显示。随胎龄增加，肽能神经元不断增多．肽能神经元广泛分布于海马的各区，但以多形层最为多见．和锥体细胞及颗粒细胞相比，肽能神经元有下列形态特点：（１）细胞形态和大小差异较大；（２）细胞突起多少不一，出现部位也无一定规律；（３）轴突投射范围小，但分枝多．Ｇｏｌｇｉ可以同时显示多种不同肽能神经元．ＧＡＢＡ阳性细胞与ＳＳ阳性细胞在发生时间和形态特点方面具有高度一致性，说明ＳＳ可与ＧＡＢＡ共存。Using Golgi method and immunohistochemical technique, various peptidergic neurons of human fetal hippocampus ofdifferent fetal age have been studied. The results showed : SS positive neurons appeared at week 19, SP positive neurons andNPY positive neurons were found at week 17, GABA positive neurons were also showed at week 16, with increasing fetalage, the peptidergic neurons were increased in number. The peptidergic neurons were distributed in all zones of hippocampuswidely, but they were often seen in polymorphic layer. As compared with pyramidal and granular cells, the peptidergic neurons had some special characters: (1)Their shape and size had obviously diversity. (2)The number of neuron's processeswas not the same, and the location of neuron's processes appeared irregular. (3)The area that axon branches could coverwas not far, but the number of branches of axon were comparatively large. Golgi method could show many sorts of peptidergic neurons. GABA positive neurons and SS positive neurons resembled each other in their structure characters. It is suggested that SS and GABA can coexist.

关 键 词：人胚胎 发育 形态学 肽能神经元 海马 

分 类 号：R322.81[医药卫生—人体解剖和组织胚胎学] R329.1[医药卫生—基础医学]