复方苦豆子对肾性高血压大鼠左室肥厚及血浆AngII的影响  

Effects of Compound Kudouzi on Left Ventricular Hypertrophy and AngII in Plasm of Renal Hypertensive Rats

作　　者：周颖[1] 陈虹[1] 马建慧[1] 祝世发[1] 刘小莉[1] 

机构地区：[1]石河子大学药学院,新疆石河子832002

出　　处：《石河子大学学报（自然科学版）》2006年第6期705-708,共4页Journal of Shihezi University(Natural Science)

基　　金：新疆生产建设兵团医药专项资助项目(NO:04GG24)

摘　　要：为探讨复方苦豆子(CK)对肾性高血压大鼠(RHR)左室肥厚(LVH)及血浆血管紧张素II(AngII)的影响,建立了二肾一夹型高血压大鼠模型(2KⅠC-RHR),选取造模成功的大鼠57只,随机分为5组:模型组(Mod组),CK高、中、低剂量组(H、M、L组)和卡托普利组(Cap组),另取10只作为假手术组(Sham组)。每日灌药1次,连续8周。根据体重随时调整给药量。观察药物对模型动物左室肥厚指数(LVHI)及AngⅡ影响。结果表明:1)CK长期给药能明显降低模型动物的LVHI,H、M组与Mod组相比均有显著性差异(P<0.01),L组也有下降趋势,但无统计学意义。2)CK能降低模型动物血浆AngⅡ水平,与Mod组相比,各给药组均有显著性差异(P<0.01),以H组下降最为明显。这表明CK对RHR的心脏重塑有一定的防治作用,其机制可能与抑制肾素-血管紧张素系统(RAS)活性有关。To investigate the effects of compound kudouzi（CK） on left ventricular hypertrophy（LVH） and AnglI in plasm in renal hypertensive rats （RHR）,and analyze the possible mechanism. Methods：2-kidney 1-clip（2K Ⅰ C） renovaseular hypertension was induced in male wister rots.57 RHR were randomly divided into 5 groups as follows： model group（n = 11 ）, high dose of CK group（H groop）, middle dose of CK group（M group, n = 12）, low dose of CK group（L group） and eaptopril group（ Cap group, n = 10）, in addition , sham-operated group（sham group） were fed with drinking water too. All rats were treated once a day for 8 weeks, and the volumes of the drug were adjusted any time according to the changes of their weight. The left ventricular hypertrophy index（LVHI） and the levels of angiotension Ⅱ （AngⅡ） were measured. Results： Compared with model group, the LVHI were significantly decreased in H and M groups. L group had the tendency of decline, but had no significance. The concentration of AngII in plasma of H group is much lower than in moddle group（ P 〈 0.01 ）. Conlusion： Chronic use of CK can inhibit and reverse ventricular hypertropy, and the effect is relativdy dosedependent. Decreasing activity of RAS probably is one of the mechanisms.

关 键 词：复方苦豆子制剂 高血压 左室肥厚 肾性高血压大鼠 血管紧张素Ⅱ 

分 类 号：R282.71[医药卫生—中药学]