WT1基因不同转录本的生物学功能及其在造血分化中的作用  

Biological activities of WT1 gene iosforms and their functions in haematopoietic differentiation： review

作　　者：李晓红(综述)[1] 王宏伟(审校)[1] 

机构地区：[1]山西医科大学第二医院血液病研究所,太原030001

出　　处：《白血病．淋巴瘤》2007年第1期78-80,共3页Journal of Leukemia & Lymphoma

摘　　要：WT1基因是转录因子白血病发病机制的研究热点之一。通过选择性剪接可以产生四种主要转录本，各转录本表达水平差异及相互之间比例改变可能与细胞增生、分化及凋亡等过程有关。WT1在正常骨髓中低表达而在白血病细胞中异常表达，提示其在造血分化过程中可能起重要作用。Wilms tumor gene 1 as a transcription factor is the emphasis in study of molecular mechanism of tumors, especially leukemia. Alternative splicing, RNA editing, and the use of alternative translation initiation sites generate four kinds of isoforms, which seem to modify the cell proliferation, differentiation and apotosis functions by regulating their expression level and proportion. It＇ s low expression in normal marrow and abnormal expression in leukemia indicates it＇s important role in progress of hematogenic differentiation.

关 键 词：白血病 基因 肾母细胞瘤 转录本 造血干细胞移植 

分 类 号：R392.2[医药卫生—免疫学]