5-氯-2-(4-氯-苯氧基)-苯酚的合成  

Synthetic Process of Active Antimicrobial 5-Chloro-2-(4-Chloro-Phenoxy)Phenol

作　　者：焦家俊[1] 韩海军[1] 侯钰暄[1] 王静[1] 

机构地区：[1]华东理工大学化学与分子工程学院,上海200237

出　　处：《华东理工大学学报（自然科学版）》2007年第1期75-78,共4页Journal of East China University of Science and Technology

摘　　要：以对二氯苯为起始原料,经过乙酰基化、醚化、过氧乙酸氧化、水解得到5-氯-2-(4-氯-苯氧基)-苯酚,改良后的工艺使终产品收率达32.9%,醚化反应改用氢氧化钾代替碳酸钾与对氯苯酚反应制备亲核试剂,均三甲苯代替二甲苯为溶剂,醚化产物收率达到69.2%。氧化反应使用乙酸酐与过氧化氢(w=0.30)反应制备氧化剂,乙酸为溶剂,氧化反应收率达到72.7%。This paper presents an improved process for the synthesis of 5-chloro-2-（4-chloro-phenoxy）- phenol by using 1,4-dichlorobenzene as a starting material, through acetylation, etherification, acetylperoxide oxidation and hydrolysis,the total yield reached 32.90%. Mesitylene instead of xylene,was used as solvent,and potassium hydroxide instead of potassium carbonate,was used to react with phenol to generate nucleophilic reagent during etherization,through which the yield reached 69.2 %. During the acetylperoxide oxidation, with acetic acid as solvent,peracetiacid as oxidizing agent prepared through the reaction of acetic anhydride with hydrogen peroxide（w=0.30）,the yield reached 72.7 %.

关 键 词：杀菌剂 5-氯-2-(4-氯-苯氧基)-苯酚 过氧乙酸 BAEYER-VILLIGER氧化 

分 类 号：O625.1[理学—有机化学]