宫颈上皮内瘤样病变术后人乳头瘤病毒清除率评价  

Rate of human papillomavirus clearance after surgical treatment for cervical intraepithellal neoplasia

作　　者：李瑜珍[1] 余文辉[1] 周小梅[1] 王霞灵[2] 花纯宏[1] 陈佩莹[3] 陈春娟[3] 李卓华[4] 

机构地区：[1]深圳市中医院检验科,518033 [2]深圳市中医院妇产科,518033 [3]广东省汕头市第二人民医院检验科,515011 [4]广东省汕头市第二人民医院妇产科,515011

出　　处：《国际检验医学杂志》2007年第2期127-129,共3页International Journal of Laboratory Medicine

摘　　要：目的 研究宫颈上皮内瘤样病变（CIN）术后人乳头瘤病毒（HPV）的清除率。方法 109例经聚合酶链反应（PCR）技术和组织病理活检确认为宫颈HPV感染的CINⅠ～Ⅲ期女性患者，在冷冻术或锥形切除术（简称锥切术）后3、6、9、12和24个月进行HPV DNA分型，并对其性伴侣进行阴茎HPV DNA分析。结果研究对象中，81％女性患者在入选或接受治疗时HPV DNA阳性。1年后，7例女性（9％）患者的同型HPV DNA仍然阳性。大多数患者治疗3个月后被确认为HPV清除。冷冻术组患者CIN病理分级较低，且较年轻，其HPV清除率较锥切术组的低（P〈0．001）。只有4对性伴侣检测到同型HPV DNA。结论 CIN手术后通常3个月内HPV即被清除，锥切术组HPV清除率明显高于冷冻术组。Objective To investigate the rate of human papillomavirus （HPV） clearance after surgical treatment for cervical intraepithelial neoplasia （CIN）. Methods One hundred and nine women were diagnosed CIN Ⅰ-Ⅲ caused by HPV infection using biopsy and polymerase chain reaction （PCR）. They were treated with cryosurgery or conization at hospital and observed with cervical HPV deoxyribonucleic acid （DNA） testing by PCR and HPV typing at 0,3,6,9,12,24 months after treatment. Penile HPV DNA was analyzed in current sexual partners. Results Eighty-one percent of evaluable women were HPV DNA positive at treatment or enrollment. One year later, 7 women （9%） remained positive for the same HPV type. Most women had cleared the HPV infection of after 3 months treatment. The cryotherapy group had lower CIN grades,was younger,and had a lower HPV clearanee rate （P〈0. 001）. Only 4 couples had HPV DNA of the same type detected. Conclusion Surgical treatment of CIN usually results in clearance of HPV infection within 3 months,the rate of HPV clearance is significantly higher in eonization group than that of cryosurgery group.

关 键 词：宫颈上皮内瘤样病变 乳头状瘤病毒 人 预后 聚合酶链反应 

分 类 号：R711.74[医药卫生—妇产科学]