免疫时下丘脑腹内侧核神经元放电率的变化及电针、弓状核、蓝斑对其调制作用  

The Changes in Firing Rates of Ventromedial Hypothalamic Neurons and Its Modulations by Electroacupuncture, Arcuate Nucleus and Locus Coeruleus during the Immune Response

作　　者：朱笛霓[1] 赵建础[1] 王力菲 柳苏平 李春敏[1] 

机构地区：[1]陕西省中医药研究院,西安710003

出　　处：《针刺研究》1996年第3期32-35,共4页Acupuncture Research

基　　金：国家自然科学基金

摘　　要：本实验用30只成年健康SD大鼠，分成对照组、羊红血球（SRB）免疫5天组和新生期谷氨酸单钠（MS）处理+SRBC组。记录下丘腹内侧核（VMH）神经元自发放电和电针、蓝斑（LC）刺激的作用。结果如下：（1）SRBC组大鼠VMH神经元自发放电频率明显增加，MSG＋SRBC组大鼠VMH神经元自发放电频率高于对照组，低于SRBC组。各组间均有统计学差品（2）电针明显增加各组动物VMH神经元放电频率，SRBC组增加最明显，其次是MSG＋SRBC组。（3）LC刺激使SRBC组和MSG＋SRBC组多数VMH神经元呈现先激活后抑制的双相放电改变，电外可部分增加SRBC组动物LC对VMH的激活性控制。结果表明，VMH可能是免疫反应过程中重要的神经内分泌环节。电针能增强SRBC对VMH的免疫作用。LC和下丘脑弓状核区β-内啡肽神经元均参与电针对VMH免疫调节控制。30 adult SD rats were divided into 3 groups: normal control goup, SRBC immune group (on 5thday after SRBC injection) and MSG(MSG injection at newborn stage) + SRBC group. The changes ofthe spontaneous firing rates of ventromedial hypothalamus (VMH) neurons and evoked responses byelectroacupuncture (EA) and locus coeruleus (LC) stimulation were recorded. The results were as fol-lows:(1)The spontaneous firing rate of VMH neurons was significant increase in the SRBC group. Thefiring rate in the MSG + SRBC group was higher than that in the control group, and lower than that inthe SRBC group. There were statistical differences between them. (2)EA can increase the firing ratesin all groups. The effect of EA was the most significant in the SRBC group, and more significant inthe MSG + SRBC group. (3)The firing type of most VMH neurons showed first excited then inhibitedbiphasic response following stimulation LC in the SRBC and the MSG + SRBC groups. EA showedsome increase in effect of the excited modulation from LC to VMH in the SRBC group. The results. suggest that VMH might be an important neuroendocrinal link in immunoresponse. EA can increasethe immune function of SRBC on VMH. LC and β-endorphine neurons of arcuate nucleus might partic-ipate in the EA-mediated immunoresponse.

关 键 词：电针 免疫反应 下丘脑腹内侧核 神经元 放电率 

分 类 号：R338.24[医药卫生—人体生理学] R245.97[医药卫生—基础医学]