阿托伐他汀对冠心病患者颈动脉内-中膜厚度及背向散射积分的影响  

Influence of Atorvastatin on IMT and IBS of Carotid Artery in Patients with Coronary Artery Disease

作　　者：刘丽文[1] 钱蕴秋杨力军李兰荪殷忠周晓东杨丽平 钱蕴秋[1] 杨力军[2] 李兰荪[3] 殷忠[3] 周晓东[1] 杨丽平[4] 

机构地区：[1]解放军第四军医大学西京医院超声诊断科,西安市710032 [2]解放军第四军医大学西京医院泌尿外科,西安市710032 [3]解放军第四军医大学西京医院心脏内科,西安市710032 [4]解放军第四军医大学西京医院门诊特需,西安市710032

出　　处：《中国超声医学杂志》2007年第3期209-211,共3页Chinese Journal of Ultrasound in Medicine

基　　金：陕西省科技攻关项目(No.2006K13-G1)

摘　　要：目的利用高频超声观察冠心病(CAD)患者,经阿托伐他汀治疗后对颈动脉内-中膜厚度(IMT)、背向散射积分(IBS)的改善作用。方法经冠状动脉造影(CAG)确诊为CAD并伴有颈动脉粥样硬化患者59例患者,利用高频超声血管技术检测阿托伐他汀对CAD患者治疗前后颈动脉最厚处和最薄处IMT、不同性质斑块的IBS的疗效。结果阿托伐他汀组治疗2年后,冠心病患者颈动脉IMT最厚处和最薄处与治疗前相比均无显著性改变(P>0.05);脂质型斑块IBS增高,与治疗前相比差异有显著性(P<0.05);纤维型、钙化型斑块与治疗前相比无显著性差异(P>0.05);常规治疗组治疗2年后,颈动脉IMT最厚处与治疗前相比无显著性改变(P>0.05),IMT最薄处显著增厚(P<0.05);脂质型、纤维型及钙化型斑块IBS与治疗前相比均无显著性差异(P>0.05);与阿托伐他汀组治疗后及对照组相比差异有显著性(P<0.05)。结论阿托伐他汀具有稳定斑块、延缓粥样硬化斑块进展的作用。Objective To observe the effect of statins on intima media thickness （IMT） and integrated backscatter （IBS） of carotid artery in patients with coronary artery disease （CAD） using high-frequency ultrasonic imaging. Methods A total of 59 patients diagnosed with CAD and atherosclerosis of carotid artery （CA） by coronary angiography （CAG） and high-frequency ultrasound （HFLIS） were studied. HFUS was used to detect the effect of atorvastin on IMT at the thickest and thinnest points and IBS of plaques in different characteristics in CA in CAD patients. Results After 2 years＇ atorvastatin therapy, both the thickest and thinnest IMT of CA in CAD patients had no significant changes, IBSs of lipid plaques were increased significantly （P〈0.05）, and IBSs of fibrous and calcific plaques had no significant changes （P〉0.05） . In conventional therapy group, the thickest IMT of CA had no significant changes （P〉0.05）, but the thinnest IMT was thickened significantly （P〈0.05）; IBS of lipid, fibrous and calcific plaques had no significant difference （P 〉 0.05） than before. The conventional therapy group had significant difference compared with the atorvastatin and normal control groups （ all P 〈 0.05 ） Conclusions Atorvastatin was effective to stabilize the plaques and to retard the atherosclerosis development.

关 键 词：阿托伐他汀冠心病 内中膜厚度 背向散射积分 高频超声 

分 类 号：R541.4[医药卫生—心血管疾病]