心房颤动患者脑钠素的变化及其与肾素血管紧张素醛固酮系统的关系  

Relationship between brain natriuretic peptide and renin-angiotensinsystem in persistent atrial fibrillation

作　　者：于建华[1] 解朝永[1] 

机构地区：[1]枣庄市立医院内1科,山东枣庄277102

出　　处：《临床心血管病杂志》2007年第2期111-113,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨持续性心房颤动患者的血脑钠素(BNP)水平的改变及其与肾素血管紧张素醛固酮系统的关系。方法:对108例符合入选标准的住院患者分为持续性心房颤动组(55例)和对照组(53例),对2组患者的血BNP、肾素、血管紧张素Ⅱ、醛固酮水平进行检测,并行经胸超声心动图检查,测量左心房前后径。结果:2组血BNP分别为(79.65±16.23)μg/L、(50.12±15.97)μg/L(均P<0.01),多元线性逐步回归分析表明:左房内径、血管紧张素Ⅱ浓度是高血BNP水平的独立预测因素。结论:持续性心房颤动患者血BNP水平明显升高,与心房颤动患者的结构重构及肾素血管紧张素醛固酮系统密切相关。Objective：To determine the relationship between brain natriuretic peptide and renin-angiotensin-aldosterone system in atrial fibrillation. Method：One hundred and eight patients were divided into two groups： persistent atrial fibrillation group（n= 55） and control group（n= 53）. The changes of plasma brain natriuretic peptide （BNP）, renin（Ren） ,angiotensin Ⅱ （Ang Ⅱ ） and aldotone（Ald） were observed. Left atrial anteroposterior diameter of patients were checked with echocardiogram. Result：The levels of plasma BNP with persistent atrial fibrillation group and control group was （79.56±16.23） μg/L and （50. 12±15.97）μg/L respectively （P〈0. 01）. The multiple linear stepwise regression analysis revealed that the left atrial anteroposterior diameter and angiotensin Ⅱ were independent predictors of high BNP. Conclusion： The levels of plasma BNP in persistent atrial fibrillation is increased significantly. Plasma BNP is closely correlated with renin-angiotensin-aldosterone system and atrial remodeling.

关 键 词：脑钠素 心房颤动 肾素血管紧张素醛固酮系统 心房重构 

分 类 号：R541.7[医药卫生—心血管疾病]