苄基四氢巴马汀对卵母细胞膜Kv1.2通道的作用  

Effects of benzyltetrahydropalmatine on Kv1.2 channel of xenopus oocytes

作　　者：秦孺子[1] 曾秋棠[1] 李军 曹林生[1] 

机构地区：[1]华中科技大学协和医院心内科 [2]广州市天河区卫生局

出　　处：《临床心血管病杂志》2007年第2期125-127,共3页Journal of Clinical Cardiology

摘　　要：目的:研究苄基四氢巴马汀(BTHP)抗心律失常作用的分子机制。方法:比较BTHP和经典Ⅲ类抗心律失常药胺碘酮对卵母细胞膜上表达的Kv1.2通道的外向钾电流的阻滞作用。结果:BTHP和胺碘酮对Kv1.2通道的外向钾电流均有阻滞作用,在10-3～10mmol/L浓度范围内,对电流的阻滞作用增强,二者相比,差异无统计学意义。结论:BTHP能够阻滞Kv1.2通道的外向钾电流,这是其抗心律失常作用的分子机制之一。Objective： To study the molecular mechanism of benzylterahydropalmatine（BTHP） in counteracting arrhythmia. Method： To compare BTHP with classical class Ⅲ antiarrhythmic drug-amiodarone in blocking the outward potassium current of Kvl. 2 channel expressed on the membrane of xenopus oocytes. Result： Both BTHP and amiodarone could block the outward potassium current of Kv1.2. In the range of concentration from 10^-3 to 10 mmol/L, the blocking ability enhanced and there was no significant difference between them. Conclusion： BTHP can block the outward potassium current of Kv1. 2, which is one the of mechanisms for its counteracting arrhythmia.

关 键 词：苄基四氢巴马汀 胺碘酮 心律失常 钾通道 

分 类 号：R541.7[医药卫生—心血管疾病]