化学位移成像监控MR引导乙酸注射治疗兔VX2肿瘤的实验研究  

Chemical-shift MR imaging of acetic acid during MR-guided percutaneous chemical ablation therapy: experimental study

作　　者：李振伟[1] 胡道予[1] 夏黎明[1] 王承缘[1] 胡军武[1] 冯定义[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院放射科,湖北武汉430030

出　　处：《中国医学影像技术》2007年第1期5-8,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家"十五"科技攻关项目([2004]338号);同济医院人才基金[2004(1)]基金资助。

摘　　要：目的探讨化学位移成像在MR引导下VX2兔行经皮穿刺乙酸化学消融的应用价值。方法制备18只肝VX2瘤兔,在1.5T磁共振扫描仪引导下,应用FRFSET2WI化学位移成像完成实验模型及经皮肝穿刺乙酸化学消融VX2瘤兔术中的扫描。结果50%乙酸注射的相关部位信号明显的增加。在对VX2瘤兔行经皮肝穿刺乙酸化学消融时,化学位移成像乙酸弥散范围(最大层面)与大体标本肿瘤的坏死范围(最大层面)存在显著的正相关性(r=0.936)。结论化学位移成像能够用于监控MR引导化学消融肝肿瘤时乙酸的分布。Objective To study the application of chemical-shift MR imaging during percutaneous acetic acid chemical ablation procedures in rabbits bearing liver tumor. Methods VX2 tumors were carried out in 18 rabbits. Chemical-shift MR imaging was performed in phantom and VX2 tumors rabbits during percutaneous chemical ablation with FRFSE on a 1.5T MR scanner. Results Phantom data demonstrated focal increases in the observed signal in chemical-shift MR imaging that correlated well with the site of injection. The study in a hepatic VX2 tumor of rabbits revealed focal signal at the injection site. It was significant positive in the radiologic-pathologic correlation. Conclusion Chemical-shift MR imaging may be used to visualize the acetic acid distribution during percutaneous chemical ablation procedures.

关 键 词：化学位移 磁共振成像 乙酸 VX2肿瘤 

分 类 号：R445.2[医药卫生—影像医学与核医学] Q95-3[医药卫生—诊断学]