超声造影剂微泡动力学模型的对比研究  

Comparative study of the mathematical models for ultrasound contrast agents

作　　者：李飞[1] 谢理哲[1] 李德玉[1] 汪天富[2] 林江莉[2] 

机构地区：[1]四川大学生物力学工程省重点实验室,四川成都610065 [2]四川大学生物医学工程系,四川成都610065

出　　处：《中国医学影像技术》2007年第2期295-298,共4页Chinese Journal of Medical Imaging Technology

基　　金：四川省青年基金项目(04ZQ026-013)资助。

摘　　要：目的从现有的模型中选出一种造影剂微泡动力学方程，利用它能较好的为造影剂的设计及其临床应用提供具有指导意义的参数。方法将三种典型的动力学模型，即修正Herring、Allen和Hoff模型，应用于造影剂Optison，并通过与实验结果作比较，分析各个模型对造影剂在二次谐波方面的预测能力，从而对模型描述微泡非线性振动的能力做出评价。结果入射超声的驱动频率为4MHz，驱动压在0．4～2．0MPa间变化时，随着声压的增大，Allen模型计算的二次谐波越来越接近于实验结果，Hoff模型对二次谐波的仿真结果的变化趋势和变化幅度与实验结果最为接近。结论Hoff模型更适合描述造影剂微泡的非线性振动，该模型可为造影剂的设计及其临床应用提供具有指导意义的参数。Objective To find the best quantitative model of an encapsulated micro-bubbles contrast agents among existing models which can be commendably applied in the research of the UCA micro-bubbles＇ design and it＇s clinical application. Methods The predictive abilities of three typical models （modified Herring, Allen and Hoff equations） on Optison were analyzed. In order to evaluate the nonlinear oscillation describing abilities of each model, numerical simulation results of second harmonic were compared with existed experimental results. Results The numerical simulation results of second harmonic indicated that as the amplitude of driving pressure increase, the simulation results by Allen equation was close to the existed experimental results, and that by Hoff equation in trend and range was the closest to the existed experimental results. Condusion Compared with other models, the Hoff equation is the best model to describe the nonlinear oscillation of encapsulated micro-bubbles of UCA. And it is commendably applied in the research of the UCA micro-bubbles＇ design and it＇s clinical application.

关 键 词：超声 造影剂 OPTISON 二次谐波 

分 类 号：R445.1[医药卫生—影像医学与核医学]