有机磷杀虫剂引起低温反应的机制及其影响因素  

Mechanisms of organophosphorus insecticides-induced hypothermia and its relative factors

作　　者：王东[1] 何彦芳[1] 杨永录[1] 

机构地区：[1]成都医学院基础医学院,四川610081

出　　处：《中国急救医学》2007年第3期246-248,共3页Chinese Journal of Critical Care Medicine

基　　金：四川省教育厅重点项目(No2005A192)

摘　　要：临床上有机磷中毒的患者常出现低温反应。有机磷杀虫剂引起的低温反应与体内胆碱酯酶(ChE)活性降低和精氨酸升压素(AVP)释放有关。此外,环境温度、毒剂剂量和作用时间、性别差异和有机磷杀虫剂耐受性也可影响有机磷中毒引起低温反应。本文综述了有机磷杀虫剂引起低温反应的机制及其影响因素,期望为预防有机磷杀虫剂中毒提供一定理论依据,且为临床治疗有机磷中毒提供指导。Patients of organophosphorus insecticides poisoning always accompany with hypothermic response in clinic. Organophosphorus insecticides - induced hypothermia is related to the decrease of cholinesterase （ChE） activation and the release of arginine vasopressin （AVP）. Moreover, environmental temperature, the dosage and action time of toxic agents, sex differences and organophosphorus insecticides tolerance also influence organophosphorus insecticides poisoning - induced hypothermic response. In this review, we summarized the mechanisms of organophosphorus insecticides - induced hypothermic response and its relative factors in order to provide some theoretical data for the prevention and treatment of organophosphorus insecticides poisoning.

关 键 词：有机磷杀虫剂 低温 体温调节 

分 类 号：R595.4[医药卫生—内科学]