东北铁线莲化学成分研究  

Chemical constituents of Clematis manshurica

作　　者：史社坡[1] 蒋丹[2] 董彩霞[3] 屠鹏飞[1] 

机构地区：[1]北京大学药学院,北京100083 [2]东北师范大学,吉林长春130024 [3]陕西中医学院,陕西咸阳712046

出　　处：《中草药》2007年第3期335-337,共3页Chinese Traditional and Herbal Drugs

基　　金：国家"十五"重大科技专项资助项目(2004AA2Z3730)

摘　　要：目的研究东北铁线莲Clematis manshurica的化学成分。方法利用硅胶、Sephadex LH-20、PHPLC等色谱方法进行化合物的分离纯化,根据化合物的理化性质、光谱数据进行结构鉴定。结果分离得到11个化合物,分别鉴定为角鲨烯(Ⅰ)、木栓酮(Ⅱ)、正二十六烷酸(Ⅲ)、β-谷甾醇(Ⅳ)、豆甾醇(Ⅴ)、齐墩果酸(Ⅵ)、β-胡萝卜苷(Ⅶ)、5-羟甲基糠醛(Ⅷ)、丹参素甲酯(Ⅸ)、5R-5-羟甲基-2(3H)-呋喃酮(Ⅹ)、5R-5-羟甲基-2(5H)-呋喃酮(Ⅺ)。结论 11个化合物除β-谷甾醇外均为首次从东北铁线莲中分离得到。Objective To study the chemical constituents of Clematis manshurica. Methods The ex- tract from the roots and rhizomes of C. manshurica was subjected to chromatography on silica gel and Sephadex LH-20 column. The compounds obtained were identified on the basis of their physicochemical and spectroscopic evidences. Results Eleven compounds were isolated and their structures were elucidated as squalene （ Ⅰ ）, friedelin （ Ⅱ ）, hexacosoic acid （ Ⅲ ）, β-sitosterol （ Ⅳ ）, stigmasterol （ Ⅴ ）, oleanolic acid （ Ⅵ ）, β-daucosterol （Ⅶ）, 5-hydroxymethyl-2-furaldehyde （Ⅷ）, methyl 3, 4-dihydroxy-phenyl lactate （Ⅸ）, 5R-dihydro-5-hydroxymethyl-2 （3H）-furanone （X）, 5R-5-hydroxymethyl-2 （5H）-furanone （Ⅺ）. Conclusion All the compounds except for β-sitosterol are isolated from the plant for the first time.

关 键 词：东北铁线莲 铁线莲属 丹参素甲酯 

分 类 号：R284.1[医药卫生—中药学]