实施乙型肝炎疫苗免疫后19年人群乙型肝炎病毒感染状况调查  

Infective Status of HBV Among Population After 19 Years Immunization Vaccine

作　　者：田茶[1] 马景臣[2] 韩彩芝[1] 齐顺祥[1] 郝志勇[2] 张志勇[2] 陈吉朝[2] 赵卉[2] 张艳红[2] 王锋[3] 张勇[3] 毕胜利[3] 

机构地区：[1]河北省疾病预防控制中心,石家庄050021 [2]正定县疾病预防控制中心,河北正定050800 [3]中国疾病预防控制中心病毒病预防控制所,北京100052

出　　处：《中国计划免疫》2007年第1期4-7,共4页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解实施乙型肝炎（乙肝）疫苗干预措施后人群乙肝病毒（HBV）感染状况和抗体水平。方法2005年在河北省正定县试点乡8个自然村，采集人群血清标本10010份，用固相放射免疫（SPRIA）法检测血清标本的乙肝病毒表面抗原（HBsAg）和乙肝病毒表面抗体（抗-HBs），使用EPIinfo和SAS软件进行统计处理。结果免疫后人群中HBsAg平均阳性率为5．32％（标化率为4．82％），与免疫前1983年的8．57％（标化率为8．16％）相比降低了37．92％（标化率为40．93％），其中1～19岁人群HBsAg平均阳性率为1．46％，〈15岁儿童HBsAg阳性率为0．49％，明显低于免疫前同年龄组人群。免疫后整体人群保护性抗-HBs（S/N≥10．0）平均阳性率为46．86％，其中1～19岁为53．77％，明显高于免疫前1983年对应年龄组人群的38．32％。结论实施乙肝疫苗干预措施后1～19岁人群HBsAg阳性率达到低流行国家水平，≥20岁人群HBV感染情况无明显变化。Objective To understand the status of HBV infection and the level of the anti-HBs after immunization. Methods The population of 8 villages of pilot town of Zhengding County, Hebei was chosen, 10010 serum specimens were collected for detecting HBsAg and anti-HBs by SPRIA in 2005. The results were analyzed by Epi Info and SAS software. Results The average HBsAg positive rate of the population vaccinated was 5.32 % （the adfusted rate 4.82 96 ）, reduced by 37.90 % （the adjusted rate 40.90 96 ）, compared with 8.57 96 （the adjusted rate was 8.16 % ） before immunization. The average HBsAg positive rate of thepopulation aged 1 - 19 years was 1.46 96, and that of the children below 15 years was 0.49%. The average positive rate of effective anti- HBs was 46.86 96 of the vaccinated population,that of the population aged 1 -19 years was 53.77% ,which increased significantly comparing with 38.22% before immunization in 1983. Conclusion The HBsA4g positive rate of the population aged 1 - 19 years old in 2005 whose immunization reached the levels of lower infective countries,and the HBV infective levels of the population older than 20 years in 2005 was similar with that of same age population in 1983.

关 键 词：乙型肝炎疫苗 乙型肝炎病毒感染 人群 

分 类 号：R186[医药卫生—流行病学] R512.62[医药卫生—公共卫生与预防医学]