上呼吸道感染患儿肺炎链球菌血清群/型及耐药分析  

Serotyping/Grouping and Antimicrobial Resistance of Streptococcus Pneumoniae From Children With Upper Respiratory Infection

作　　者：佟月娟[1] 姚开虎[1] 俞桑洁[1] 李燕[1] 杨永弘[1] 

机构地区：[1]首都医科大学附属北京儿童医院儿科研究所,北京100045

出　　处：《中国计划免疫》2007年第1期75-78,共4页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解患上呼吸道感染的0～5岁儿童肺炎链球菌的血清群／型及其对抗生素耐药情况。探讨肺炎链球菌疫苗在中国儿童使用的意义。方法取患儿鼻咽分泌物，分离出137株肺炎链球菌。采用荚膜肿胀法（Quellinngtest）进行血清群／型分析。E-test及K．B纸片扩散法检测对青霉素等13种抗生素的敏感性。结果疫苗相关血清型占63％，最常见的血清群／型为19、6、23、14。青霉素不敏感率为33％，较往年增高。青霉素耐药菌株对头孢类抗生素有交叉耐药性，红霉素、阿奇霉素耐药率达94％，应引起临床高度重视。结论疫苗相关血清群／型在0～5岁儿童覆盖率较高，肺炎链球菌疫苗的使用有利于降低儿童肺炎链球菌感染的发病率，有助于减少抗生素耐药的产生。Objective To evaluate streptococcus pneumonia serotypes and antimicrobial resistance in children and discuss the significance for vaccination. Methods 137 strains isolated from nasopharyngeal swabs of 0-5 years old patients with upper respiratory disease were serotyped using capsular swelling test. The antimicrobial resistance were analysized with E-test and Kirdy-Bauer method. Resuits The 7-valent pneumoccal conjugate vaccine related serotypes/groups were found in 63 % of the isolates. The most prevalent serogroups/serotypes are 19,6,23, and 14. Penicillin non-susceptable rate is 33 % ,showing an increasing trend compared to previous years. Pecilline resistance strains showed a cross-resistance to some cefsporins. Erythromycin and azthromycin resistance covered 94 % of isolates, calling for clinical attention. Conclusion High prevalence of vaccine related serotypes/groups among children with upper respiratory infection suggested the need of vaccination to prevent the strepcoccal pneumoniae infection disease and it is helpful in reducing reduce the antibiotic resistance.

关 键 词：肺炎链球菌 血清型 耐药 

分 类 号：R378.12[医药卫生—病原生物学]