心内直视术中患者血浆PGE_2水平变化及其负性免疫调节作用  

Clinical changes in plasma prostaglandin E_2 levels and its inhibitory immunomodulation during and after cardiopulmonary bypass

作　　者：翟中云[1] 董春姣[1] 

机构地区：[1]湖北省潜江市江汉油田中心医院,433124

出　　处：《中华麻醉学杂志》1996年第10期489-491,共3页Chinese Journal of Anesthesiology

摘　　要：为了探讨心内直视术体外循环(CPB)对患者血浆前列腺素E_2(PGE_2)含量影响及PGE_2与CPB后免疫功能关系,选择了30例心内直视术患者,分别监测术前、CPB60分、120分、术毕、术后第1、7、14天外周静脉血血浆PGE_2水平和外周血淋巴细胞白介素-2受体(IL-2R)表达及诱生白介素-2能力变化。结果显示CPB中PGE_2急剧升高,是基础值的10倍,术毕及术后第7天仍高于基础值(P<0.05),而IL-2R表达及诱生能力则明显被抑制,与PGE_2水平呈负相关。提示心内直视术后细胞免疫功能障碍与PGE_2水平升高有关。To study the dynamics of venous plasma level of prostaglandin E_2 (PGE_2),and the relationship between PGE_2 level and immunity during and after CPB, 30 patients scheduled for open heart surgery served as the subjects. The peripheral venous blood samples were taken to measure plasma PGE_2 concentration,the expression of interleukin-2 receptor (IL-2R) on the lymphocyte membrane,and productive ability of interleukin-2 (IL-2),before and during CPB,on 1st ,7th and 14th day postoperatively,respectively. During CPB the PGE_2 level significantly ascended to the highest level,following cessation of CPB,went down but still remained higher level than baseline,even on 1st and 7th day postoperatively; Simultaneously, IL-2R expression and IL-2 generation were markedly suppressed, which were correlated negatively with the PGE_2 levels. It is suggested that cellular immunodepression induced by CPB,is partly related to the increase of plasma PGE_2, level.

关 键 词：体外循环 心内直视术 前列腺素E2 免疫调节 

分 类 号：R654.1[医药卫生—外科学]