糖尿病患者血清肿瘤坏死因子-α水平与糖尿病肾病的关系  

Relationship between serum levels of tumor necrosis factor-α and diabetic nephropathy in diabetes patients

作　　者：纪志尚[1] 刘秀英[1] 

机构地区：[1]青岛市第八人民医院,山东省266100

出　　处：《实用诊断与治疗杂志》2007年第3期181-182,184,共3页Journal of Practical Diagnosis and Therapy

摘　　要：目的:分析糖尿病患者血清肿瘤坏死因子-α和尿蛋白排泄率之间的关系。方法:用酶联免疫法对60例糖尿病和40例对照组血清肿瘤坏死因子-α水平进行测定。结果:2型糖尿病患者血清肿瘤坏死因子-α水平显著升高且随糖尿病肾病的进展而升高,ARBs类药物(缬沙坦)治疗6周后微量蛋白尿组血清肿瘤坏死因子-α水平较治疗前明显下降。结论:糖尿病患者的血清肿瘤坏死因子-α水平和糖尿病肾病之间关系密切,ARBs类药物可延缓糖尿病肾病的进展。Objective To analyze the clinical relationship between serum levels of tumor necrosis factor-α and urinary albumin excretion. Methods Clinical history of 60 cases of type 2 diabetes mellitus were reviewed. Results （1） Significant differences in serum＇levels of tumor necrosis factor-α were observed between the patients and control subjects （P〈0. 01）. （2） Tumor necrosis factor-α levels were increased in diabetic patients with the developing of urinary albumin excretion （P〈0.01）. （3） Serum levels of tumor necrosis factor-α in diabetic patients with microalbuminuria were significantly decreased after treated with ARBs 6 weeks later（P〈0.01）. Conclusion Serum levels of tumor necrosis factor-α may play some etiopathogenic roles in diabetic nephropathy, and ARBs may be an effective therapy for preventing the development of diabetic nephropathy.

关 键 词：糖尿病 肿瘤坏死因子-Α 尿蛋白排泄率 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]