正交实验法优选清心沉香八味滴丸制备工艺  

Optimization of the Preparation Process of Qingxin Chenxiang Bawei Dropping Pills by Orthogonal Design

作　　者：景舒[1] 马志平[1] 

机构地区：[1]内蒙古医学院,内蒙古呼和浩特010059

出　　处：《时珍国医国药》2007年第2期453-454,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的采用正交实验法优选清心沉香八味滴丸的制备工艺。方法以基质种类、药物与基质配比、药液温度、冷却剂温度作为考察因素进行正交实验，用3个指标评定工艺的优劣。结果最佳制备工艺条件为：以PECA000-PEG6000（2：1）为基质，药物与基质配比为1：2．5，药液温度为95℃，冷却剂温度为8～10℃。结论优选得到的工艺简便易行，有良好的重现性和可操作性。Objective To optimize the preparation process of Qingxin Chenxiang Bawei dropping pills by orthogonal design. Methods Using the kind of base, ratio between drug and base, the temperature of drug solution and the temperature of cooler as affecting factors, the orthogonal test was conducted, to assess the preparation process good or bad in the three indexes. Results The optimized preparation process was as follows： PEG4000-PEC,6000（2： 1 ） was optimal bases, ratio between drug and base was 1： 2.5, the temperature of drug solution was 95℃, the temperature of cooler was 8 - 10℃. Conclusion The optimized preparation process is simple and practicable, with good reproducibility.

关 键 词：清心沉香八味滴丸 正交实验 制备工艺 

分 类 号：R283[医药卫生—中药学] R291.2[医药卫生—中医学]