高频超声照射下血卟啉镓配合物对脱氧核糖核酸的损伤  

Damage of Deoxyribonucleic Acid under High Frequency Ultrasonic Irradiation in the Presence of Hematoporphyrin-Ga Complex

作　　者：王君[1] 熊大珍[1] 张朝红[2] 张向东[1] 陈立江[3] 赵红丹[1] 邢志强[1] 徐锐[1] 

机构地区：[1]辽宁大学化学系,沈阳110036 [2]辽宁大学环境系,沈阳110036 [3]辽宁大学制药系,沈阳110036

出　　处：《无机化学学报》2007年第3期479-483,共5页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金项目(No.20371023);辽宁省教育厅自然科学基金项目(No.2004C018)资助

摘　　要：用紫外-可见(UV-Vis)光谱和荧光(FL)光谱研究了高频超声波激活血卟啉镓(HP-Ga)配合物对脱氧核糖核酸(DNA)的损伤,并探讨了超声波照射时间、HP-Ga浓度、溶液酸度和离子强度等因素对DNA损伤的影响。结果表明,在一定条件下,DNA的损伤程度随着超声波照射时间的增加和HP-Ga浓度的增大而加剧,而溶液酸度和离子强度的影响则较为复杂。The damage of deoxyribonucleic acid （DNA） under the action of hematoporphyrin-Ga （HP-Ga） complex activated by ultrasound was detected by means of ultraviolet-visible （UV-Vis） and fluorescence （FL） spectroscopy, and the influences of ultrasonic irradiation time, HP-Ga concentration, solution acidity and ionic strength were also discussed. The results showed that under a certain condition, the damage of DNA could be enhanced with the increase of ultrasonic irradiation time and HP-Ga concentration. However, the influences of solution acidity and ionic strength on the damage of DNA were more complicated.

关 键 词：超声波 血卟啉镓(HP—Ga)配合物 损伤 脱氧核糖核酸(DNA) 

分 类 号：O614.371[理学—无机化学] O657.3[理学—化学]