奥司他韦治疗流行性感冒的临床随机对照研究  

A Randomized and Controlled Clinical Evaluation of Oseltamivir in the Treatment of Influenza

作　　者：陈旭岩[1] 谭伟 汪波[1] 于净[1] 简忠[1] 冯莉莉[1] 

机构地区：[1]北京大学第一医院急诊科,北京市100034

出　　处：《中国全科医学》2007年第4期272-274,共3页Chinese General Practice

摘　　要：目的观察奥司他韦治疗流行性感冒(简称流感)的临床疗效。方法采用随机、对照、开放性的临床试验设计。入选患者70例,可分析疗效病例共47例,随机分为两组,试验组22例,服用奥司他韦75mg,2次/d,共5d;对照组25例,接诊医生按既往经验给予药物治疗。结果两组患者发热、肌痛、乏力缓解时间,鼻卡他/鼻塞、咽喉痛、头痛、发冷/出汗症状持续时间间差异均有统计学意义(P<0.05);两组患者咳嗽缓解时间间差异无统计学意义(P>0.05)。与对照组相比,试验组抗菌药物使用率及急诊临时输液率均降低(P<0.05);两组患者的并发症发生率和药物不良反应发生率间差异均无统计学意义(P>0.05)。结论奥司他韦能够明显缩短流感主要症状持续时间,减少抗菌药物使用,降低患者临时输液率,且安全性好。Objective To observe the efficacy of oseltamivir in the treatment of influenza. Methods A randomized, open, control clinical trial was designed, 70 patients were enrolled and 45 individuals were identified as influenza - infected. 45 patients were divided into two groups at random： oseltamivir group （22 cases, oseltamivir 75 rag, twice a day for 5 days） and control group （25 cases, treated with the physician＇s routine orders）. Results The symptom remission time of fever, muscular ache and fatigue of patients in osehamivir group were significantly shorter than control group （ P 〈0.01 ） ; The durations of coryza/nasal congestion, sore throat, headache and chills/sweats were shorter （ P 〈 0. 05 ） ; There was no difference in the symptom remission time of cough between two groups （ P 〉 0. 05 ）. The usage rate of antibiotics and incidence of temporary infusion were much less in osehamivir group than control group （ P 〈0. 05 ）. The rate of complications and drug adverse reactions were similar in two groups （ P 〉0. 05）. Conclusion Oseltamivir is effective and well tolerated in the treatment of influenza. It decreases the usage rate of antibiotics and the temporary infusion.

关 键 词：流感 奥司他韦 抗菌药物 随机对照试验 

分 类 号：R511.7[医药卫生—内科学]