肾上腺皮质系统在电针调节免疫反应中的作用  

The Effects of Pituitory-adrenal System in the EA-modulating Immune Responses

作　　者：刘文琴[1] 赵续民[1] 赵建础[1] 朱笛霓[1] 赵岗[1] 薛峰 赵爱玲 张晓彬[1] 王力菲 

机构地区：[1]陕西省中医药研究院,西安710003

出　　处：《针刺研究》1996年第2期71-76,共6页Acupuncture Research

基　　金：国家自然科学基金

摘　　要：本工作目的在于研究垂体-肾上腺系统在针刺调节免疫反应中的作用。我们发现小鼠的多种免疫反应在应用氢化可的松后明显降低；而在肾上腺切除的小鼠，则见明显增高。电针对氢化可的松降低的脾IL－2、LTT含量可使其回升至正常水平，但对氢化可的松降低的血凝抗体、溶血抗体效价没有影响。在肾上腺切除的小鼠，除牌LZM显示降低外，其它免疫指标如脾PFC、IL－2、LTT、血清IgG及胸腺LZM含量均显著增高。肾上腺切除鼠给予电针后。已降低的脾LZM可回复至正常，但肾上腺切除后而增高的一些免疫反应，电针却没有明显影响．其免疫反应水平与单纯肾上腺切除动物几乎相同。上述结果提示，垂体-肾上腺系统在电针调节免疫反应中的作用，可能主要起抑制性影响。文中对正常针刺下增强免疫反应的作用与该系统的可能关系，作了简要讨论。The aim of this work was to investigate the role of pituitory-adrenal system in the electroacupuncture modulating immune responses. We found that the multiple immune responses were declined in mice receiving cortisol ip. treatment, whereas it could be increased in mice of adrenalectomy.The IL-2,LTT contents declined by cortisol could be restored to normal levels by EA, however, the hemolytic antibody and hemoagglutinatirig antibody titer declined by cortisol were not affected by EA.In the adrenalectomized mice, except spleen LZM was declined, all the other immune parameters such as spleen PFC, IL-2, LTT, serum IgG and thymus LZM contents were increased. The EA could restore the declined spleen LZM in adrenalectomized mice to normal, but the other elevated immune parameters by adrenalectomy were not affected by EA, the immune levels were almost the same as that in the single adrenalectomy group.The above results indicate that pituitory-adrenal system may principally play an inhibitory effect in hte EA-modulating immune responses.

关 键 词：免疫调节 肾上腺皮质 肾上腺切 电针疗法 

分 类 号：R245.97[医药卫生—针灸推拿学] R277.599.3[医药卫生—中医临床基础]