大鼠丘脑中央下核神经元对电刺激腓神经和“足三里”穴的反应  

Responses of Neurons in Thalamic Nucleus Submedius to Electrical Stimulation of Peroneal Nerve and "Zusanli" Point in Rats

作　　者：杨杰[1] 唐敬师[2] 袁斌[2] 贾红[2] 

机构地区：[1]延安医学院生理教研室 [2]西安医科大学生理学教研室,西安710061

出　　处：《针刺研究》1996年第4期28-33,共6页Acupuncture Research

基　　金：国家自然科学基金!3947087

摘　　要：本文采用玻璃微电极细胞外记录的方法，观察了大鼠丘脑中央下核（Sm）神经元对电刺激腓神经和“足三里”穴区的反应，结果表明：大多数（81％）Sm神经元对兴奋腓神经C波的阈刺激发生反应，所有（100％）神经元对2—3倍阈刺激发生反应，且随着刺激强度和脉冲数的增加而增加；电刺激“足三里”穴区也有与此相同的反应，但引起反应的阈值明显高于刺激腓神经。这些结果为脊髓-SM－VLO-PAG-脊髓痛调制负反馈环路参与针刺镇痛，尤其是细纤维镇痛的设想提供了支持。The experiments were performed on the anesthetized rats. Single unit was recorded extracellularlly from the thalamic nucleus submedius (Sm) with glass micropipettes. The responses of Sm neurons were examined to electrical stimulation of the peroneal nerve and 'Zusanli' point. The results show that most (81%) of the neurons in Sm responded to electrical stirnulation of the peroneal nerve with afferent C fiber excitation, and this response increased following increase of the stimulation intensity and pulse numbers. It was found that electrical stimulation of the 'Zusanli' point could activate the Sm neuronal activities with higher intensity threshold compared to that of the peroneal nerve stimulation, and the response properties of Sm neurons to acupoint stimuli were similar to those to stimulation of peroneal nerve. These results provide support for the hypothesis that a negative feedback loop consisting of spinal cord-Sm-VLO-PAU-spinal cord responsible for nociceptive modulation is involved in acupuncture analgesia, especially in analgesia produced by electroacupuncture-evoked activation of the afferent C fibers

关 键 词：电针 腓神经刺激 "足三里"穴 丘脑中央下核 大鼠 

分 类 号：R245.97[医药卫生—针灸推拿学]