头孢呋辛酯片处方研究及其溶出度考察  

Study on formulation and dissolution of cefuroxime axetil tablets

作　　者：庄美芳[1] 缪婧[1] 

机构地区：[1]江苏南通市中医院,南通226001

出　　处：《海峡药学》2007年第2期12-15,共4页Strait Pharmaceutical Journal

摘　　要：目的通过对头孢呋辛酯片处方的改进来提高其溶出度。方法通过不同组方筛选适宜的辅料和用量,并通过正交试验研究了微晶纤维素的用量、羧甲基淀粉钠的用量、粘合剂浓度对头孢呋辛酯片溶出度的影响。结果微晶纤维素为110mg/片,羧甲基淀粉钠(CMS-Na)为15mg/片,聚维酮(PVP)为6%时,头孢呋辛酯片的溶出能达到中国药典2005年版附录对溶出度的要求。结论采用合适的辅料与工艺,可显著地改善头孢呋辛酯片的溶出度。OBJECTIVE To improve the dissolution of cefuroxime axetil tabltes by improving formulation. METHODS Different prescriptions were tested to screen the proper excipients and their doses. The orthogonal test design was used to optimize the amount of microcrystalline cellulose and sodium carboxymethyl starch, and concentration of polyvinylpyrrolidone for good dissolution. RESULTS When the amount of microcrystalline cellulose was 110 mgper tablet sodium carboxymethyl starch was 15mg per tablet and the concentration of polyvinylpyrrolidone was 6%, the dissolution of cefuroxime axetil tablets could according with regulation of dissolution in pharmacopeia2005 of china. CONCLUSION The dissolution of cefuroxime axetil tablets can be greatly improved by using suitable excipients and the technology of preparation.

关 键 词：头孢呋辛酯片 处方 溶出度 

分 类 号：R978.11[医药卫生—药品]