COL4A1基因Q1334H多态性与中国男性骨密度显著相关性研究  

Significant associations of the COL4A1 gene Q1334H polymorphism with bone mineral density in Chinese men

作　　者：吴涤[1] 洪秀梅[1] 杨天鹏[1] 李志平[1] 臧桐华[1] 

机构地区：[1]安徽医科大学生物医学研究所,安徽合肥230032

出　　处：《中国现代医学杂志》2007年第3期269-271,共3页China Journal of Modern Medicine

基　　金：安徽省自然科学基金资助项目;项目编号01043802

摘　　要：目的研究COL4A1基因多态性与中国农村男性骨密度关系。方法采用双能X线吸收仪对367名男性研究对象进行腰椎及股骨扫描,应用PCR-限制性片段长度多态性(PCR-RFLP)方法检测COL4A1基因Q1334H多态位点基因型,用广义线性模型分析此位点多态性与腰椎2￣4及股骨骨密度关系。结果在调整环境危险因素前后,均显示COL4A1基因H1334H基因型与股骨颈骨密度降低呈显著相关(P=0.0074)、但与腰椎2￣4的骨密度无显著相关性(P=0.351)。结论在中国农村男性人群中COL4A1基因Q1334H多态性与股骨颈骨密度相关。[Objective] In order to investigate the association of polymorphism of collagen type Ⅳ alpha 1 gene （COL4A1） with bone mineral density （BMD） in Chinese rural men. [Methods] The bone mineral density was measured at the lumbar spine and femur using dual-energy X-ray absorptiometry in 367 study subjects. PCR-restriction fragment length polymorphism （PCR-RFLP） was applied to examine Q1334H polymorphism of the COL4A1 gene. Generalized linear model was used to analyse the association of this polymorphism with the bone mineral density of the lumbar spine （L2-4） and femur. [Results] Without or with adjustment for environmental covariates, significant correlation was found between the Q1334H polymorphism of the COL4A1 gene and lower femoral neck BMD （p= 0.0074）. but no significant correlation was found between Q1334H polymorphism of the COL4A1 gene and BMD of the lumbar spine （L2-4）. [Conclusion] There is significant relationship between the Q1334H polymorphism of the COL4A1 gene and BMD of femoral neck in Chinese rural men population.

关 键 词：Ⅳ型胶原α链(COL4A1) 多态性 相关性 骨矿物质密度(BMD) 

分 类 号：R18[医药卫生—流行病学]