新型仿生聚合物胶束用于纳米药物载体的研究  

Novel Biomimetic Polymeric Micelles for Drug Delivery

作　　者：徐建平[1] 陈伟东[1] 计剑[1] 沈家骢[1] 

机构地区：[1]浙江大学高分子科学与工程学系教育部高分子合成与功能构造重点实验室,杭州310027

出　　处：《高等学校化学学报》2007年第2期394-396,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:50373036);教育部霍英东基金优选资助项目(批准号:J20040212)资助

摘　　要：Novel amphiphilic polymers,cholesterol-end-capped poly(2-methacryloyloxyethyl phosphorylcholine)(CMPC) was specially designed as the drug delivery systems.Cytotoxicity of this novel amphiphiles was not observed as indicated by cell culture.Anti-cancer drug adriamycin(ADR) was incorporated into the micelles by oil-in-water method.The release of ADR from the nanosphere continued over 7 d.The drug-loaded micelles could effectively restrain the growth of cancer cell.These results suggest that the drug loaded nanoparticles could be a good candidate for injectable drug delivery carrier.Novel amphiphilic polymers, cholesterol-end-capped poly （2-methacryloyloxyethyl phosphorylcholine） （CMPC） was specially designed as the drug delivery systems. Cytotoxicity of this novel amphiphiles was not observed as indicated by cell culture. Anti-cancer drug adriamycin （ADR） was incorporated into the micelles by oil-in-water method. The release of ADR from the nanosphere continued over 7 d. The drug-loaded micelles could effectively restrain the growth of cancer cell. These results suggest that the drug loaded nanoparticles could be a good candidate for injectable drug delivery carrier.

关 键 词：聚合物胶柬 细胞膜仿生 药物缓释 生物相容性 磷酸胆碱 

分 类 号：O631.3[理学—高分子化学]