米索前列醇阴道后穹窿给药用于足月妊娠引产140例  

Misoprostol placed in the posterior fornix of vagina for inducing term labor in 140 cases

作　　者：任喜捷 

机构地区：[1]河南省卫辉市华新医院,卫辉453100

出　　处：《中原医刊》2007年第5期16-17,共2页Central Plains Medical Journal

摘　　要：目的 探讨小剂量米索前列醇（米索）用于足月妊娠引产的有效性和安全性。方法 A组140例根据宫颈Bishop评分阴道后穹窿首次置米索25μg，观察宫缩情况，若无规律宫缩则每3小时置药1次（25μg）直至出现规律宫缩，总量不超过200μg；B组140例静滴缩宫素引产作为对照组。结果 两组引产成功率分别为87．86％和81．43％（P〉0．05）。A组从开始用药至临产的平均时间较B组明显缩短（P〈0．05）。宫缩评分≤5的产妇A组引产成功率高于B组（P〈0．05），两组剖宫产率，产时出血量及新生儿窒息的发生率间差异无统计学意义。结论 小剂量重复阴道后宫窿给米索用于足月妊娠引产是一种安全、有效、方便的方法．且效果优于缩宫素。Objective To study the efficacy and safety of misoprostol placed in the posterior. Methods 140 patients of group A were placed 25μg misoprostol in the posterior fornix of vagina according to Bishop scores of cervix ,25μg misoprostol was given vaginally every 3 hours until the regular uterine contraction appeared. The total dosage was less than 200μg per day. 140 patients of group B received intravenous oxytocin as control group. Results The success rate of labor induction was 87. 86% in group A and 81.43% in group B（ P 〉0. 05）. The average interval from medication to in labor in group A was significantly shorter than that of group B （ P 〈 0. 05 ）. When the cervix of primipara was unfavorable for induction （Bishop score ≤5）, the success rate in group A was higer than that of group B （ P 〈0. 05）. There were no significant differences in the incidence of cesarean section, volume of bleeding and neonatal asphyxia between the two groups. Conclusion It is safe and effective to induce term labor by repeatedly placing lower dosage misoprostol in the posterior of vagina.

关 键 词：米索前列醇 足月妊娠 引产 剂量 

分 类 号：R7[医药卫生—临床医学]