巨噬细胞的极化及其意义  

The Polarization of Macrophages and Its Significance

作　　者：张凤[1] 熊思东[1] 

机构地区：[1]复旦大学免疫生物学研究所免疫学系,上海200032

出　　处：《细胞生物学杂志》2007年第1期27-30,共4页Chinese Journal of Cell Biology

摘　　要：表型可变性和功能多样性是单个核吞噬细胞的重要特征。近年来巨噬细胞的极化受到关注。一般认为极化巨噬细胞是单核细胞活化后一系列功能状态两个极端。而它的分化受到各种微环境信号的诱导与调节。极化的巨噬细胞能够进一步影响局部免疫反应,与各种因子协同作用调节病原体微生物感染结局和肿瘤免疫,参与免疫调节,组织修复重塑过程。对巨噬细胞亚型诱导因素及功能的研究将有助于了解免疫反应的调节机制。Plasticity and functional polarization are hallmarks of the mononuclear phagocyte system. Recent studies show that fully polarized M1 and M2 （or alternatively activated） macrophages are the extremes of a continuum of functional states. Moreover, the differentiation of monocytes is induced and regulated by microenvironmental factors. And polarized macrophages, interacting with other local molecules can regulate the immunoreactions against microbial pathogens and rumors. Knowledge about the characteristics and inducer of macrophage subsets would help to know more about the regulation of immune response.

关 键 词：巨噬细胞 极化 

分 类 号：R392.1[医药卫生—免疫学]