七氟醚对犬血流动力学影响的实验研究  

Experimentalstudyoftheeffectofsevofluraneonhemodynamicsindogs

作　　者：李树人[1] 韩如泉[1] 槐庆元[1] 

机构地区：[1]首都医科大学附属北京友谊医院麻醉科

出　　处：《中华麻醉学杂志》1996年第11期543-546,共4页Chinese Journal of Anesthesiology

摘　　要：选用成年杂种犬１１只，应用Ｓｗａｎ－Ｇａｎｚ漂浮导管，热稀释法测定心输出量，观察０．５、１．０、１．５ＭＡＣ七氟醚对体循环和肺循环血流动力学的影响。结果表明：心率随吸入浓度增加呈下降趋势；平均动脉压及左室泵血功能指标均呈剂量相关性下降；不同浓度间体循环血管阻力无显著性差异；同基础值相比，肺动脉压下降，但与吸入浓度增加无关，１．５ＭＡＣ时肺循环血管阻力增加４０％（Ｐ＜０．０５）。结果提示：七氟醚呈剂量相关性抑制循环功能，其引起动脉压下降主要是抑制心肌收缩力的结果；七氟醚对肺循环影响轻微。Inordertoassesstheefectofsevoflurane(Sevo)onhemodynamics,elevenhealthydogsactedasthesubjectsinthisstudy.Folowinganestheticinductionwiththiopental(15mg/kg)andtra-chealintubation,0.2%succinycholinewasinfusedformaintenanceofmuscularrelaxation.Theanesthet-icandCO2concentrationswerecontinuouslymonitoredusinganinfraredanalyzer.A5-FSwan-Ganzcatheterwasinsertedviatherightfemoralveinformonitoringpressureandcardiacoutputusingther-modilutiontechniques.Withtheanimalinaquietstateforatleast15hours,succinycholineinfusionwasdiscontinuedandthebaselinewasmeasmed.The0.5,1.0,1.5MACofSevowasgiveninarandomizedconcentrationorder.Alvaribleswererecordedaftera30minequilibrationateachconcentration.Sevoresultedinbradycardia,adose-dependentdecreaseinfemoralarterypressure,cardiacoutput,leftven-tricularstrokeworkindexandrate-pressureproduct.Therewerenosignificantdiferencesinsystemicvascularresistanceamongthethreeconcentrations.Comparedwiththebaselines,meanpulmonaryarterypressuredecreasedby26%,26%and28%(P<0.01),respectively;however,pulmonaryvascularresistanceincreasedby40%(P<0.05)at1.5MACconcentration.Theresultsdemonstratethatthede-pressedefectsonhemodynamicsofSevoareassociatedwithinhaledconcentrationsandthedecreaseofarterypressureismainlyresultedfromdepessionofmyocardialcontractibility.

关 键 词：七氟醚 血流动力学 麻醉药 

分 类 号：R614.21[医药卫生—麻醉学] R971.2[医药卫生—外科学]