NO与PGE_1对肺动脉高压犬血流动力学影响的对比研究  

Influenceofnitricoxideinhalationonhemodynamicsinpulmonaryhypertensivedogs:AcomparisonwithprostaglandinE1

作　　者：刘明华[1] 毕敏[1] 

机构地区：[1]第三军医大学西南医院ICU

出　　处：《中华麻醉学杂志》1996年第11期547-550,共4页Chinese Journal of Anesthesiology

摘　　要：对比研究了吸入ＮＯ与静脉输注ＰＧＥ１治疗肺微血管栓塞肺动脉高压犬的血流动力学效果，结果表明，ＮＯ与ＰＧＥ１均显著降低肺动脉压和肺循环阻力，但ＰＧＥ１显著影响体循环，而ＮＯ组心率、血压和体循环阻力均无明显变化，提示ＮＯ比ＰＧＥ１更具有肺血管扩张选择性，治疗肺动脉高压ＮＯ明显优于ＰＧＥ１。Toevaluatetheefectsofnitricoxide(NO)onhemodynamicsinpulmonaryhypertensivedogs,eighteenadultmongreldogswithpulmonaryhypertensioninducedbymicroemboli,wererandomlydividedintothreegroups,eachreceivedintravenousnormalsaline,prostaglandinE1(PGE1)orinhaledNOfortwohours.Alhemodynamicparameterswerestableinthecontrolgroup;Thereweresignificantdecreaseinmeanpulmonaryarterypressure(MPAP)andpulmonaryvascularresistanceindex(PVRI)whileheartrate(HR),meansystemicarterypressure(MSAP),systemicvascularresistanceindex(SVRI)toNo,andcardiacindex(CI)remainedstableininhaledNOgroup;PGE1hadsimilarefectonMPAPandPVRI,buthadasingnificantinfluenceonsystemiccirculation.Theresultssuggestthatin-halingNOhasseletivevasculardilatationeffectonpulmonarycirculationandissuperiortoPGE1inthetreatmentofpulmonaryhypertension.

关 键 词：一氧化氮 前列腺素E1 肺动脉高压 血流动力学 

分 类 号：R543.205[医药卫生—心血管疾病]