异丙酚与氯胺酮催眠的相互作用  被引量:27

Propofol hypnotic interaction with ketamine

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作  者:郑吉健[1] 靳凤玲[2] 金清尘[2] 李钊[2] 

机构地区:[1]潍坊医学院麻醉系,山东省261042 [2]北京医科大学第三医院

出  处:《中华麻醉学杂志》1996年第7期304-306,共3页Chinese Journal of Anesthesiology

摘  要:为研究异丙酚与氯胺酮复合的催眠作用,选择健康昆明小鼠200只,体重21~26g,随机分成A、B、C、D、E组,每组又分成5个亚组,每个亚组(n=8)给予一个预先设定的剂量,其水平呈递增,A、E组分别为异丙酚(腹腔给药)、氯胺酮(皮下给药)的单独用药组,B、C、D组为两药复合组。给药后观察翻正反射消失情况,超过10秒钟为睡眠状态。采用等效线图分析法和代数分析法处理所得数据。结果表明:氯胺酮与异丙酚分别以1:1.32、1:5.28、1:0.33比例复合时,其ED_(50)值均在相加等效线的左下方;且与单独用药ED_(50)比值之和均小于1.0。由此可见,异丙酚和氯胺酮的催眠作用之间存在着明显的协同作用。The aim of this study was to investigate the hypnosis of the combination of propofol and ketamine. Two hundred healthy Kunming mites were randomly divided into five groups, and each groups included five subgroups receiving five designed doses in turn. Propofol or ketamine was administered in traperitoneally or subcutanously. The combination of propofol and ketamine was given in group Ⅱ, Ⅲ and Ⅳ, and propofol or ketamine in group Ⅰ or Ⅴ. The abolition of righting reflex lasting 10 seconds served as the parameter for hypnosis The data were treated with algebraic analysis. When the dose ratios of ketamine to propofol were 1 : 1.32, 1 : 5.28 and 1 : 0.33, the combined ED_(50) values were much more lower than those of the theoretical additive ED_(50). The sums of ratios of combined ED_(50) to single ED_(50) were less than 1.0. It is concluded that there is a hypnotic synergism between propofol and ketamine in mice

关 键 词:异丙酚 氯胺酮 协同作用 麻醉药 

分 类 号:R971.2[医药卫生—药品] R614.24[医药卫生—药学]

 

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