人工蛹虫草子实体对小鼠免疫功能的影响  

Effects of Artificial Cordyceps Militaris on Immunity Function of Mice

作　　者：左克源[1] 裘军[1] 李维亮[1] 邵怡[1] 张进芳[1] 

机构地区：[1]华中科技大学同济医学院药学院药理教研室,武汉430030

出　　处：《医药导报》2007年第3期227-229,共3页Herald of Medicine

基　　金：广东省东莞市科研发展专项基金项目(基金编号:2005D034)

摘　　要：目的考察人工蛹虫草子实体对小鼠免疫功能的影响。方法采用蛹虫草子实体微粉（粒径17～20μm）水溶液给小鼠连续灌胃12d，分别观察对小鼠脾淋巴细胞转化、血清溶血素水平和2，4-二硝基氟苯（DNFB）诱导小鼠迟发型变态反应的影响。结果小鼠灌胃给予蛹虫草子实体微粉水溶液10～90mg·kg^-1，可显著促进淋巴细胞的自然增殖作用（与阴性对照组比较，P〈0．05），但对刀豆蛋白（ConA）或脂多糖（LPS）活化后的细胞无协同作用，同时增加血清溶血素水平，能增强DNFB诱导的小鼠迟发型变态反应，但对小鼠胸腺指数和脾脏指数无明显影响。结论人工蛹虫草子实体的微粉具有免疫调节作用。Objective To investigate the influence of artificial cordyceps militaris on the immunity function of mice. Methods Continuous intragastric administration was performed for 12 days using micro-powder aqueous solution of cordyceps Militaris with particle diameters of 17 -20 μm. The convert proliferation of splenic lymphocytes, the serum hemolysin level, and the delayed allergy induced by 2, 4-dinitrofluorobenzene （DNFB） in mice were studied respectively. Results The micro powder aqueous solution given by ig（ 10 - 90 mg·kg^-1 ） could significantly promote the natural proliferation of lymphocyte invivo （compared with negative control group, P 〈 0. 05 ） and increase the level of hemolysin, but there was no synergistic effect on cells after activating by ConA and LPS . The micro-powder of cordyceps militaris could also enhance the function of delayed allergy in mice induced by dinitrofluorobenzene. There were no effects on thymus index and spleen index. Conclusion The micro-powder of artificial cordyceps militaris exhibits an effect on immune regulation.

关 键 词：冬虫夏草属 淋巴细胞 溶血素类 变态反应 

分 类 号：R282.71[医药卫生—中药学] R285.5[医药卫生—中医学]