侯氏黑散对MCAO大鼠大脑皮质TGF-β_1 bFGF蛋白表达的影响  

Effects of Houshihei San on Cerebral Focal TGF-β_1 bFGF of MCAO Model in the Rat

作　　者：张秋霞[1] 赵晖[1] 

机构地区：[1]首都医科大学中医药学院,北京100069

出　　处：《辽宁中医杂志》2007年第2期238-240,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：北京市教育委员会科技基金(KM2003100025099)

摘　　要：目的:观察侯氏黑散对MCAO(大脑中动脉闭塞模型)大鼠大脑皮质TGF-β1、bFGF蛋白表达的影响。方法:采用线栓法复制大鼠大脑中动脉闭塞模型,利用免疫组化方法观察大鼠大脑中动脉闭塞模型皮质TGF-β1、bFGF蛋白表达的变化,通过给大鼠连续14天灌胃侯氏黑散13g.kg-1.d-1,观察其对TGF-β1、bFGF蛋白表达的影响。结果:侯氏黑散以促进TGF-β1阳性蛋白的表达,与模型组比较具有显著意义;侯氏黑散可以促进bFGF蛋白的表达,但与模型组相比,没有统计学的意义。结论:侯氏黑散治疗中风的机理可能是通过促进TGF-β1蛋白的表达,保护和修复缺血性脑损伤。Objective： To observe the effects of Houshihei San on cerebral focal TGF - β1 ,bFGF of MCAO model in the rat. Methods： MCAO model was replicated by string ligation and the change of TGF - β1 , bFGF protein expression was detected by immunohistochemical ABC method . We observed the effects of Houshihei San on cerebral focal TGF-β1 ,bFGF protein expression after 14 days treatment （13g · kg^-1· d^-1）. Result： In comparison with model group, Houshihei San can accerlate the TGF -β1 protein expression with statistical meaning and improve the bFGF protein expression without statistical meaning. Conclusion ： The mechanism of Houshihei San treating stroke maybe is that it can accerlate the TGF -β1 protein expression in order to protect and repair the ischemia injury.

关 键 词：侯氏黑散 大脑中动脉闭塞 转化生长因子 碱性成纤维细胞因子 

分 类 号：R285.5[医药卫生—中药学]