岩黄连提取物主要药效学及急性毒性试验  

Study on main pharmacodynamics and acute toxicity of herba Corydalis saxicolae extract

作　　者：黄兴振[1] 刘雪萍[1] 黄敏[1] 黄增琼[1] 李迪[1] 蒋伟哲[1] 

机构地区：[1]广西医科大学第一附属医院新药研究开发中心,广西南宁530027

出　　处：《中国医院药学杂志》2007年第2期146-148,共3页Chinese Journal of Hospital Pharmacy

基　　金：广西壮族自治区科技厅科技攻关项目(编号:桂科攻0322024-5G)

摘　　要：目的:研究岩黄连提取物与主治功能相关的主要药效学指标及安全性。方法:通过岩黄连提取物对四氯化碳和对乙酰氨基酚所致急性肝损伤的保护作用,对大鼠胆汁流量、免疫功能的影响进行了研究,同时进行急性毒性试验。结果:岩黄连提取物大剂量能明显减轻肝组织受损程度,对对乙酰氨基酚所致的急性肝损伤也有一定的保护作用,能明显提高细胞吞噬功能;岩黄连提取物的LD50为298.5mg.kg-1。结论:岩黄连提取物有显著的保护肝脏等作用,且毒性较小。OBJECTIVE To study the main pharmacodynamics and toxicity of herha Corydalis saxicolae extract. METHODS Through the test to observe the pharmacodynamics of herba Corydalis saxicolae extract. The tests showed that herba Corydalis Saxicolae extract could protect the liver damage that caused by carbon tetrachloride and acetaminophen. Meanwhile it could also have effect on immune function and Bile flow in rats; the median lethal dose was determined. RESULTS The damage of hepatic tissue was significantly decreased by the large dose of herba Corydalis saxicolae extract; it had effect on the liver damage induced by acetaminophen; it could improve immune function obviously ,the median lethal dose was 298. 5 mg·kg^-1. CONCLUSION Herba Corydalis saxicolae extract have marked effect of protecting the liver in rats with minor toxicity.

关 键 词：岩黄连提取物 药效学 急性毒性试验 

分 类 号：R285.6[医药卫生—中药学]