肺心病呼吸衰竭患者血清和尿β_2-微球蛋白测定的意义  

Significance of serum and urine β_2-MG determination in cor pulmonale with respiratory failure

作　　者：罗溶溶[1] 焦桂萍[1] 乐万祥[1] 吴瑞明[1] 

机构地区：[1]贵州省人民医院

出　　处：《遵义医学院学报》1996年第1期23-25,共3页Journal of Zunyi Medical University

摘　　要：用放免法测定62例肺心病并发呼吸衰竭患者的血清和尿β2—微球蛋白（β2—MG）水平，并以77例健康人为对照。结果表明肺心病并呼衰者血清和尿β2—MG明显高于对照组，且呼衰急发期明显高于缓解期（P＜0．01）。血清β2—MG与Cr和BUN呈正相关（r＝0．393和0．484，P＜0．01），尿β2—MG与血Cr和BUN亦呈正相关（r＝0．194，和0．217），但无统计学意义（P＞0．05）同时还发现血清和尿β2—MG与PaO2呈负相关（r＝－0．293，和－0．258，P＜0．05），与PaC（）。呈正相关（r＝0．384，和0．357，P＜0．01）。提示肺心病肾功能改变与呼衰有关，血清及尿的β2—MG水平可能是识别患者肾功能的较敏感指标。Serum and ucine β2-MG levels were determined in 62 patients with cor pulmonale who had respiratory failure and in 77 healths using radio immunoassay The results showed that serum β2-MG and urine β2-MG levels in the patients were much higher than that in control, and were also higher in acute phase of respi-ratory failure than that in remisslon phase. Statistical analysis revealed that serum β2-MG levels possitively correlated with Cr and BUN(r=0. 393,and 0. 484,P<0.01 ) and urine β2-MG levels also possitively correlated with Cr and BUN (r = 0.194,and 0. 217), but no signiflcance in statistics (P>0.05 ). The results also showed that serum β2-MG and urine β2-MG levels negatively correlated with PaO2(r=0.293, and -0. 258,P<0.05),and possitively correlated with PaO2 r=0. 384 and 0.357,P<0.01). We suggest that renal function changes in cor pulmonale correlate with respiratory failure,and β2-MG may be a sensitive marker for identifying re-nal dysfunction in cor pulmonale with respiratory failure.

关 键 词：Β2-微球蛋白 肺心病 呼吸衰竭 肾功能不良 

分 类 号：R541.502[医药卫生—心血管疾病]