槐胺碱的免疫抑制作用  

SUPPRESSION OF SOPHORAMINE ON IMMUNE FUNCTION

作　　者：张佩[1] 李淑华[1] 张云生[1] 金英 丁丽 

机构地区：[1]丹东市第四医院,锦州市中医院

出　　处：《锦州医学院学报》1996年第1期1-3,共3页Journal of Jinzhou Medical College

摘　　要：本文以脾脏溶血空斑形成，Ｅ花环试验，ＣｏｎＡ诱导的淋巴细胞转化及白细胞介素－２（ＩＬ－２）活性测定为检测指标，观察槐胺碱（ＳＡ）对正常小鼠免疫功能的影响。ＳＡ１５、２０ｍｇ／ｋｇ降低Ｅ花环形成率，抑制ＣｏｎＡ诱导的淋巴细胞转化及ＩＬ－２的产生，但对脾脏溶血空斑形成无明显影响。ＳＡ２５ｍｇ／ｋｇ则减少脾脏溶血空斑形成，降低Ｅ花环形成率，抑制ＣｏｎＡ诱导的淋巴细胞转化及ＩＬ－２的产生。表明ＳＡ为一种免疫抑制剂。we observed the effects of sophoramine(SA)on immune function in normal mice.SA15、20mg/kg decreased the rate of E rosette,suppressed T lymphocyte transformation and IL-2 production.The hemolytic plaque of spleen were not influenced by SA15、20mg/kg.At the doses of 25mg/kg,SA decreased the rate of E rosette,suppressed T lymphocyte transformation and IL-2 production,while it reduced the hemolytic plaque of spleen.The result showed that SA is an immunosuppressive agent.

关 键 词：槐胺碱 免疫抑制剂 

分 类 号：R979.5[医药卫生—药品] R967[医药卫生—药学]