尿微量蛋白和尿酶在儿童过敏性紫癜早期肾损伤中的临床意义  

Clinical research into renal early injury indexes in children with Henoch-Schonlein purpura.

作　　者：陈华[1] 张亚京[1] 王鑫[1] 要利明[2] 郝景丽[1] 任静[1] 黄学英[1] 张玲玲[1] 

机构地区：[1]内蒙古医学院第三附属医院儿科,内蒙古包头014010 [2]内蒙古医学院第三附属医院检验科,内蒙古包头014010

出　　处：《中国实用儿科杂志》2007年第2期111-113,共3页Chinese Journal of Practical Pediatrics

摘　　要：目的探讨尿微量蛋白和尿酶在过敏性紫癜(HSP)患儿早期肾损伤中的作用和临床意义。方法2004-10—2005-10在内蒙古医学院第三附属医院儿科和皮肤科住院的HSP患儿共43例,采用免疫散射比浊法和酶法测定患儿尿微量白蛋白(MA)、转铁蛋白(TRF)、β2微-球蛋白(β2-MG)和尿酶N-乙酰-β-D氨-基-葡萄糖胺酶(NAG)的水平,同时检测尿常规和血尿素氮(BUN)、肌酐(Scr)水平。结果HSP患儿尿4项指标明显高于对照组,4项指标异常率79.07%(34/43),尿常规异常率13.95%(6/43);37例尿常规正常者4项指标异常率达70.57%(28/37),且4项指标较单项指标异常发生率高。结论尿4项指标联合检测是诊断HSP早期肾损伤的灵敏指标,可作为临床早期诊断、早期干预治疗以降低肾损伤程度的可靠依据。Objective To investigate the action and clinical significance of urine microprotein and NAG as indexes of renal early injury,in children with Henoch-Schonlein purpura（HSP）. Methods We measured urine micro protein and enzyme by immune scatter turbidimetry and enzymatic assay,and at the same time did urine routine analysis,examined blood urea nitrogen（ BUN ） and serum creatinine（Scr） in the 43 cases of HSP. Results In 43 cases group the four indexes were obviously higher than control group,abnormal rate of urine routine analysis being 13.95% ,abnormal rate of the four indexes 79. 07% ; 37cases of normal urine routine analysis had abnormal four indexes, being 70. 57% , and abnormal rate of the four index were higher than that of the single index. Conclusion Combined four indexes in urine is a sensitive index to find renal early injury in HSP, and could be credibility index in early diagnosis, treatment and in achieving favorable prognosis.

关 键 词：紫癜 过敏性 早期肾损伤 尿微量蛋白 N-乙酰-β—D-氨基-葡萄糖胺酶 儿童 

分 类 号：R72[医药卫生—儿科]