鼠伤寒杆菌核糖体制剂用作血吸虫抗原佐剂的探讨  

ADJUVANT EFFECT OF SALMONELLA TYPHIMURIUM RIBOSOME ON SCHISTOSOME ANTIGEN

作　　者：王建军[1] 刘述先[1] 

机构地区：[1]中国预防医学科学院寄生虫病研究所

出　　处：《中国寄生虫学与寄生虫病杂志》1996年第3期234-236,共3页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：目的：探讨鼠伤寒杆菌核糖体制剂对血吸虫抗原的佐剂作用。方法：小鼠分别用鼠伤寒杆菌核糖体制剂（ＳＴＲＰ）加日本血吸虫成虫抗原（ＳＷＡ）和日本血吸虫成虫抗原免疫后，其体液免疫水平用ＥＬＩＳＡ检测，保护性免疫力用减虫率表示。结果：用ＳＴＲＰ＋ＳＷＡ免疫的小鼠的抗体水平显著高于单用ＳＷＡ免疫的小鼠。尾蚴攻击感染后，ＳＴＲＰ＋ＳＷＡ免疫组小鼠和ＳＷＡ免疫组小组的减虫率，分别为４７％和１７％，前者高于后者。结论：ＳＴＲＰ可以增强小鼠对血吸虫抗原的体液免疫应答反应，并且可诱导小鼠产生较强的抗尾蚴攻击感染能力。AIM:To explore the adjuvant effect of Salmonella typhimurium ribosome preparation (STRP)on adult schistosome antigen (SWA). METHOD:Mice were immunized with STRP+SWA and SWA, respectively.Humoral immunity levels of mice were detected by ELISA and protective immunity of mice were indicated by worm reduction rate. RESULTS:The antibody level of mice immunized with STRP+SWA was significantly higher than that of mice immunized with SWA. After cercariae challenge infection,the worm reduction rate of mice immunized with STRP+SWA was also significantly higher than that of mice immunized with SWA. CONCLUSION:It is suggested that STRP can enhance the humoral response of mouse to SWA and elicit stronger resistance to schistosome cercariae challenge infection.

关 键 词：鼠伤寒杆菌 核糖体 血吸虫 抗原左剂 佐剂 

分 类 号：R532.210.3[医药卫生—内科学] R383.24[医药卫生—临床医学]