咯萘啶与磺胺多辛-乙胺嘧啶单剂及两天疗法加伯氨喹治疗恶性疟的效果  

COMPARATIVE STUDIES ON THE TREATMENT OF DRUG RESISTANT FALCIPARUM MALARIA WITH SINGLE DOSE OR TWO DAY REGIMENS OF PYRONARIDINE/SULFADOXINE PYRIMETHAMINE PLUS PRIMAQUINE

作　　者：黄在松 蒙锋[1] 符式刚[1] 

机构地区：[1]海南省热带病防治研究所

出　　处：《中国寄生虫学与寄生虫病杂志》1996年第4期314-317,共4页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：WHO/TDR资助

摘　　要：目的：在海南省多重抗性恶性疟流行区，观察咯萘啶加伯氨喹与磺胺多辛－乙胺嘧啶加伯氨喹两种方案治疗恶性疟的效果。方法：采用咯萘啶与磺胺多辛－乙胺嘧啶各５００ｍｇ、１０００ｍｇ、５０ｍｇ单剂口服以及３药各８００ｍｇ、１０００ｍｇ、５０ｍｇ２ｄ分服，同时各加伯氨喹４５ｍｇ２ｄ分服，治疗恶性疟各５０例。结果：平均退热时间分别为３９．８±２７．２ｈ和４２．１±２０．５ｈ，原虫无性体转阴时间分别为４６．９±１３．３ｈ和５１．０±１４．２ｈ，２４ｈ减虫率分别为８０％和７８％。２８ｄ治愈率皆为１００％。药物副反应较轻，一般不需特殊处理，但两组各有３例发生溶血反应，心电图有窦性心动过缓或伴窦性心律不齐。结论：表明两种方案均可治愈抗性恶性疟。AIM: To observe the comparative effects of pyronaridine/sulfadoxine pyrimethamine with single dose or two day regimens in combination with primaquine in 2 endemic areas of multidrug resistant falciparum malaria in Hainan Island. METHOD: A total of 100 patients with acute falciparum malaria were randomly divided into 2 groups. Group A was orally administered with a single dose of pyronaridine(PND) 500 mg/sulfadoxine(S)1 000 mg and pyrimethamine(P) 50 mg composite plus primaquine(Pq)22.5 mg, 24 hours later Pq 22.5 mg was given again; and Group B received a dose of PND 400 mg/S 500 mg and P 25 mg composite plus Pq 22.5 mg daily for 2 days. RESULTS: The average fever subsidence time of groups A and B was 39.8±27.2 and 42.1±20.5, the asexual parasite clearance time was 46.9±13.3 and 51±14.1 ( P >0.05), the rates of asexual parasite eliminated within 24 hours were 80% and 78%, respectively; the asexual parasite clearance rate within 28 days of both groups was 100%. Gametocytes were cleared within 21 days. The side effects were mild, but hemolysis reaction occurred in 3 cases of each group. CONCLUSION: Both presented regimens could cure multidrug resistant falciparum malaria.

关 键 词：多重抗性 恶性 疟疾 咯萘啶 磺胺多辛 乙胺嘧啶 

分 类 号：R531.305[医药卫生—内科学]